| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| Cphy_2374 | guaA | Cphy_2374 | Cphy_0264 | Rod shape-determining protein MreC; Involved in formation and maintenance of cell shape. | GMP synthase, large subunit; Catalyzes the synthesis of GMP from XMP. | 0.472 |
| Cphy_2374 | minC | Cphy_2374 | Cphy_2371 | Rod shape-determining protein MreC; Involved in formation and maintenance of cell shape. | Septum site-determining protein MinC; Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization; Belongs to the MinC family. | 0.963 |
| Cphy_2374 | polA | Cphy_2374 | Cphy_2803 | Rod shape-determining protein MreC; Involved in formation and maintenance of cell shape. | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity. | 0.433 |
| Cphy_2374 | secF | Cphy_2374 | Cphy_0716 | Rod shape-determining protein MreC; Involved in formation and maintenance of cell shape. | Protein-export membrane protein, SecD/SecF family; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA; Belongs to the SecD/SecF family. SecD subfamily. | 0.644 |
| Cphy_2374 | tgt | Cphy_2374 | Cphy_3438 | Rod shape-determining protein MreC; Involved in formation and maintenance of cell shape. | Queuine tRNA-ribosyltransferase; Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form th [...] | 0.508 |
| Cphy_3437 | guaA | Cphy_3437 | Cphy_0264 | TIGRFAM: preprotein translocase, YajC subunit; PFAM: YajC family protein; KEGG: cdf:CD2801 putative protein translocase subunit. | GMP synthase, large subunit; Catalyzes the synthesis of GMP from XMP. | 0.544 |
| Cphy_3437 | polA | Cphy_3437 | Cphy_2803 | TIGRFAM: preprotein translocase, YajC subunit; PFAM: YajC family protein; KEGG: cdf:CD2801 putative protein translocase subunit. | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity. | 0.618 |
| Cphy_3437 | queA | Cphy_3437 | Cphy_2280 | TIGRFAM: preprotein translocase, YajC subunit; PFAM: YajC family protein; KEGG: cdf:CD2801 putative protein translocase subunit. | S-adenosylmethionine--tRNA-ribosyltransferase- isomerase; Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA). | 0.506 |
| Cphy_3437 | secF | Cphy_3437 | Cphy_0716 | TIGRFAM: preprotein translocase, YajC subunit; PFAM: YajC family protein; KEGG: cdf:CD2801 putative protein translocase subunit. | Protein-export membrane protein, SecD/SecF family; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA; Belongs to the SecD/SecF family. SecD subfamily. | 0.997 |
| Cphy_3437 | tgt | Cphy_3437 | Cphy_3438 | TIGRFAM: preprotein translocase, YajC subunit; PFAM: YajC family protein; KEGG: cdf:CD2801 putative protein translocase subunit. | Queuine tRNA-ribosyltransferase; Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form th [...] | 0.860 |
| guaA | Cphy_2374 | Cphy_0264 | Cphy_2374 | GMP synthase, large subunit; Catalyzes the synthesis of GMP from XMP. | Rod shape-determining protein MreC; Involved in formation and maintenance of cell shape. | 0.472 |
| guaA | Cphy_3437 | Cphy_0264 | Cphy_3437 | GMP synthase, large subunit; Catalyzes the synthesis of GMP from XMP. | TIGRFAM: preprotein translocase, YajC subunit; PFAM: YajC family protein; KEGG: cdf:CD2801 putative protein translocase subunit. | 0.544 |
| guaA | lepA | Cphy_0264 | Cphy_2315 | GMP synthase, large subunit; Catalyzes the synthesis of GMP from XMP. | GTP-binding protein LepA; Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre- translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP- dependent manner. | 0.675 |
| guaA | polA | Cphy_0264 | Cphy_2803 | GMP synthase, large subunit; Catalyzes the synthesis of GMP from XMP. | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity. | 0.870 |
| guaA | ruvB | Cphy_0264 | Cphy_1334 | GMP synthase, large subunit; Catalyzes the synthesis of GMP from XMP. | Holliday junction DNA helicase RuvB; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. | 0.650 |
| guaA | secF | Cphy_0264 | Cphy_0716 | GMP synthase, large subunit; Catalyzes the synthesis of GMP from XMP. | Protein-export membrane protein, SecD/SecF family; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA; Belongs to the SecD/SecF family. SecD subfamily. | 0.505 |
| guaA | tgt | Cphy_0264 | Cphy_3438 | GMP synthase, large subunit; Catalyzes the synthesis of GMP from XMP. | Queuine tRNA-ribosyltransferase; Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form th [...] | 0.715 |
| guaA | truB | Cphy_0264 | Cphy_2771 | GMP synthase, large subunit; Catalyzes the synthesis of GMP from XMP. | tRNA pseudouridine synthase B; Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs; Belongs to the pseudouridine synthase TruB family. Type 1 subfamily. | 0.951 |
| lepA | guaA | Cphy_2315 | Cphy_0264 | GTP-binding protein LepA; Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre- translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP- dependent manner. | GMP synthase, large subunit; Catalyzes the synthesis of GMP from XMP. | 0.675 |
| lepA | polA | Cphy_2315 | Cphy_2803 | GTP-binding protein LepA; Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre- translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP- dependent manner. | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity. | 0.760 |