node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Cphy_1345 | Cphy_3350 | Cphy_1345 | Cphy_3350 | PFAM: prephenate dehydratase; Chorismate mutase; KEGG: ckl:CKL_0789 PheA. | KEGG: cac:CAC1655 bifunctional enzyme phosphoribosylformylglycinamidine (FGAM) synthase (synthetase domain/glutamine amidotransferase domain); TIGRFAM: phosphoribosylformylglycinamidine synthase; PFAM: AIR synthase related protein domain protein. | 0.734 |
Cphy_1345 | Cphy_3847 | Cphy_1345 | Cphy_3847 | PFAM: prephenate dehydratase; Chorismate mutase; KEGG: ckl:CKL_0789 PheA. | TIGRFAM: glutamine amidotransferase of anthranilate synthase; PFAM: glutamine amidotransferase class-I; KEGG: cth:Cthe_0874 glutamine amidotransferase of anthranilate synthase. | 0.980 |
Cphy_1345 | hisI | Cphy_1345 | Cphy_2782 | PFAM: prephenate dehydratase; Chorismate mutase; KEGG: ckl:CKL_0789 PheA. | TIGRFAM: phosphoribosyl-ATP diphosphatase; PFAM: phosphoribosyl-AMP cyclohydrolase; phosphoribosyl-ATP pyrophosphohydrolase; KEGG: cth:Cthe_2889 phosphoribosyl-AMP cyclohydrolase; In the C-terminal section; belongs to the PRA-PH family. | 0.853 |
Cphy_1345 | topA | Cphy_1345 | Cphy_2722 | PFAM: prephenate dehydratase; Chorismate mutase; KEGG: ckl:CKL_0789 PheA. | DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...] | 0.480 |
Cphy_1345 | trpA | Cphy_1345 | Cphy_3842 | PFAM: prephenate dehydratase; Chorismate mutase; KEGG: ckl:CKL_0789 PheA. | Tryptophan synthase, alpha subunit; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. | 0.755 |
Cphy_1345 | trpB | Cphy_1345 | Cphy_3843 | PFAM: prephenate dehydratase; Chorismate mutase; KEGG: ckl:CKL_0789 PheA. | Tryptophan synthase, beta subunit; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. | 0.755 |
Cphy_1345 | trpC | Cphy_1345 | Cphy_3845 | PFAM: prephenate dehydratase; Chorismate mutase; KEGG: ckl:CKL_0789 PheA. | PFAM: Indole-3-glycerol phosphate synthase; KEGG: msi:Msm_1143 indole-3-glycerol phosphate synthase, TrpC; Belongs to the TrpC family. | 0.807 |
Cphy_1345 | trpD | Cphy_1345 | Cphy_3846 | PFAM: prephenate dehydratase; Chorismate mutase; KEGG: ckl:CKL_0789 PheA. | Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). | 0.813 |
Cphy_1345 | trpE | Cphy_1345 | Cphy_3848 | PFAM: prephenate dehydratase; Chorismate mutase; KEGG: ckl:CKL_0789 PheA. | Anthranilate synthase component I; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentr [...] | 0.979 |
Cphy_1345 | trpF | Cphy_1345 | Cphy_3844 | PFAM: prephenate dehydratase; Chorismate mutase; KEGG: ckl:CKL_0789 PheA. | PFAM: N-(5'phosphoribosyl)anthranilate isomerase (PRAI); KEGG: cac:CAC3159 phosphoribosylanthranilate isomerase; Belongs to the TrpF family. | 0.819 |
Cphy_3350 | Cphy_1345 | Cphy_3350 | Cphy_1345 | KEGG: cac:CAC1655 bifunctional enzyme phosphoribosylformylglycinamidine (FGAM) synthase (synthetase domain/glutamine amidotransferase domain); TIGRFAM: phosphoribosylformylglycinamidine synthase; PFAM: AIR synthase related protein domain protein. | PFAM: prephenate dehydratase; Chorismate mutase; KEGG: ckl:CKL_0789 PheA. | 0.734 |
Cphy_3350 | hisI | Cphy_3350 | Cphy_2782 | KEGG: cac:CAC1655 bifunctional enzyme phosphoribosylformylglycinamidine (FGAM) synthase (synthetase domain/glutamine amidotransferase domain); TIGRFAM: phosphoribosylformylglycinamidine synthase; PFAM: AIR synthase related protein domain protein. | TIGRFAM: phosphoribosyl-ATP diphosphatase; PFAM: phosphoribosyl-AMP cyclohydrolase; phosphoribosyl-ATP pyrophosphohydrolase; KEGG: cth:Cthe_2889 phosphoribosyl-AMP cyclohydrolase; In the C-terminal section; belongs to the PRA-PH family. | 0.932 |
Cphy_3350 | topA | Cphy_3350 | Cphy_2722 | KEGG: cac:CAC1655 bifunctional enzyme phosphoribosylformylglycinamidine (FGAM) synthase (synthetase domain/glutamine amidotransferase domain); TIGRFAM: phosphoribosylformylglycinamidine synthase; PFAM: AIR synthase related protein domain protein. | DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...] | 0.608 |
Cphy_3350 | trpF | Cphy_3350 | Cphy_3844 | KEGG: cac:CAC1655 bifunctional enzyme phosphoribosylformylglycinamidine (FGAM) synthase (synthetase domain/glutamine amidotransferase domain); TIGRFAM: phosphoribosylformylglycinamidine synthase; PFAM: AIR synthase related protein domain protein. | PFAM: N-(5'phosphoribosyl)anthranilate isomerase (PRAI); KEGG: cac:CAC3159 phosphoribosylanthranilate isomerase; Belongs to the TrpF family. | 0.596 |
Cphy_3847 | Cphy_1345 | Cphy_3847 | Cphy_1345 | TIGRFAM: glutamine amidotransferase of anthranilate synthase; PFAM: glutamine amidotransferase class-I; KEGG: cth:Cthe_0874 glutamine amidotransferase of anthranilate synthase. | PFAM: prephenate dehydratase; Chorismate mutase; KEGG: ckl:CKL_0789 PheA. | 0.980 |
Cphy_3847 | hisI | Cphy_3847 | Cphy_2782 | TIGRFAM: glutamine amidotransferase of anthranilate synthase; PFAM: glutamine amidotransferase class-I; KEGG: cth:Cthe_0874 glutamine amidotransferase of anthranilate synthase. | TIGRFAM: phosphoribosyl-ATP diphosphatase; PFAM: phosphoribosyl-AMP cyclohydrolase; phosphoribosyl-ATP pyrophosphohydrolase; KEGG: cth:Cthe_2889 phosphoribosyl-AMP cyclohydrolase; In the C-terminal section; belongs to the PRA-PH family. | 0.795 |
Cphy_3847 | trpA | Cphy_3847 | Cphy_3842 | TIGRFAM: glutamine amidotransferase of anthranilate synthase; PFAM: glutamine amidotransferase class-I; KEGG: cth:Cthe_0874 glutamine amidotransferase of anthranilate synthase. | Tryptophan synthase, alpha subunit; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. | 0.988 |
Cphy_3847 | trpB | Cphy_3847 | Cphy_3843 | TIGRFAM: glutamine amidotransferase of anthranilate synthase; PFAM: glutamine amidotransferase class-I; KEGG: cth:Cthe_0874 glutamine amidotransferase of anthranilate synthase. | Tryptophan synthase, beta subunit; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. | 0.992 |
Cphy_3847 | trpC | Cphy_3847 | Cphy_3845 | TIGRFAM: glutamine amidotransferase of anthranilate synthase; PFAM: glutamine amidotransferase class-I; KEGG: cth:Cthe_0874 glutamine amidotransferase of anthranilate synthase. | PFAM: Indole-3-glycerol phosphate synthase; KEGG: msi:Msm_1143 indole-3-glycerol phosphate synthase, TrpC; Belongs to the TrpC family. | 0.999 |
Cphy_3847 | trpD | Cphy_3847 | Cphy_3846 | TIGRFAM: glutamine amidotransferase of anthranilate synthase; PFAM: glutamine amidotransferase class-I; KEGG: cth:Cthe_0874 glutamine amidotransferase of anthranilate synthase. | Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). | 0.999 |