ANB37687.1 protein (Rhodovulum sulfidophilum)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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a 3D structure is known or predicted

Edges:

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:

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[Homology]

Score

ANB37687.1

Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (194 aa)

Predicted Functional Partners:

ANB37682.1

0.713

ANB37685.1

0.676

ANB37686.1

0.664

ANB37684.1

0.648

ANB37683.1

0.600

BauD

0.567

ANB38434.1

0.481

ANB36792.1

0.457

ANB36706.1

0.456

WcbR

0.438

Your Current Organism:

Rhodovulum sulfidophilum

NCBI taxonomy Id: 35806
Other names: ATCC 35886, LMG 5201, LMG:5201, R. sulfidophilum, Rhodobacter sulfidiphilus, Rhodobacter sulfidophilus, Rhodopseudomonas sulfidophila, strain Hansen W4

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ANB36706.1	ANB37687.1	A6024_01430	A6024_06965	Multidrug transporter; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.456
ANB36792.1	ANB37687.1	A6024_01890	A6024_06965	ABC transporter substrate-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.457
ANB37682.1	ANB37683.1	A6024_06935	A6024_06940	Ferric anguibactin-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Iron ABC transporter ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.994
ANB37682.1	ANB37684.1	A6024_06935	A6024_06945	Ferric anguibactin-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Iron ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.994
ANB37682.1	ANB37685.1	A6024_06935	A6024_06955	Ferric anguibactin-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	ABC transporter ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.731
ANB37682.1	ANB37686.1	A6024_06935	A6024_06960	Ferric anguibactin-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	ABC transporter ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.697
ANB37682.1	ANB37687.1	A6024_06935	A6024_06965	Ferric anguibactin-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.713
ANB37682.1	BauD	A6024_06935	A6024_06950	Ferric anguibactin-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Iron ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.994
ANB37683.1	ANB37682.1	A6024_06940	A6024_06935	Iron ABC transporter ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Ferric anguibactin-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.994
ANB37683.1	ANB37684.1	A6024_06940	A6024_06945	Iron ABC transporter ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Iron ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.997
ANB37683.1	ANB37685.1	A6024_06940	A6024_06955	Iron ABC transporter ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	ABC transporter ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.691
ANB37683.1	ANB37686.1	A6024_06940	A6024_06960	Iron ABC transporter ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	ABC transporter ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.675
ANB37683.1	ANB37687.1	A6024_06940	A6024_06965	Iron ABC transporter ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.600
ANB37683.1	BauD	A6024_06940	A6024_06950	Iron ABC transporter ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Iron ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.993
ANB37684.1	ANB37682.1	A6024_06945	A6024_06935	Iron ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology.	Ferric anguibactin-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.994
ANB37684.1	ANB37683.1	A6024_06945	A6024_06940	Iron ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology.	Iron ABC transporter ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.997
ANB37684.1	ANB37685.1	A6024_06945	A6024_06955	Iron ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology.	ABC transporter ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.730
ANB37684.1	ANB37686.1	A6024_06945	A6024_06960	Iron ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology.	ABC transporter ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.695
ANB37684.1	ANB37687.1	A6024_06945	A6024_06965	Iron ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.648
ANB37684.1	BauD	A6024_06945	A6024_06950	Iron ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology.	Iron ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.990

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Network Stats

number of nodes:

11

number of edges:

33

average node degree:

6

avg. local clustering coefficient:

0.934

expected number of edges:

10

PPI enrichment p-value:

2.27e-08

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006099

Tricarboxylic acid cycle

8 of 26

2.45

6.9

3.60e-15

GO:0019752

Carboxylic acid metabolic process

5 of 339

1.13

0.76

0.0094

GO:0044281

Small molecule metabolic process

6 of 622

0.95

0.65

0.0094

GO:0044237

Cellular metabolic process

10 of 3101

0.47

0.33

0.0195

GO:0044238

Primary metabolic process

10 of 3357

0.44

0.29

0.0379

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0008177

Succinate dehydrogenase (ubiquinone) activity

2 of 2

2.96

1.14

0.0087

GO:0046912

Acyltransferase activity, acyl groups converted into alkyl on transfer

2 of 11

2.22

0.84

0.0280

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005739

Mitochondrion

7 of 709

0.96

0.77

0.0018

GO:0005737

Cytoplasm

11 of 4006

0.4

0.3

0.0152

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:8804

Tricarboxylic acid cycle, and Biotin transport and metabolism

9 of 41

2.3

7.15

6.47e-17

CL:8807

Tricarboxylic acid cycle, and Aspartate metabolic process

7 of 24

2.43

6.19

1.44e-13

CL:8832

Tricarboxylic acid cycle

4 of 10

2.57

3.51

2.17e-07

CL:8808

Tricarboxylic acid cycle, and Aspartate metabolic process

3 of 12

2.36

2.11

0.00010

CL:8834

Fumarate reductase complex, and 3Fe-4S

2 of 5

2.57

1.28

0.0046

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00020

Citrate cycle (TCA cycle)

8 of 33

2.35

6.89

8.05e-16

map01200

Carbon metabolism

8 of 121

1.78

3.9

6.28e-12

map00630

Glyoxylate and dicarboxylate metabolism

4 of 38

1.99

2.55

3.87e-06

map01210

2-Oxocarboxylic acid metabolism

3 of 28

1.99

1.97

9.86e-05

map01110

Biosynthesis of secondary metabolites

7 of 447

1.16

1.35

3.87e-06

(more ...)

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-71403

Citric acid cycle (TCA cycle)

6 of 25

2.34

4.72

2.10e-10

MAP-71406

Pyruvate metabolism and Citric Acid (TCA) cycle

6 of 44

2.1

3.94

2.25e-09

MAP-1428517

The citric acid (TCA) cycle and respiratory electron transport

6 of 121

1.66

2.43

4.72e-07

MAP-1430728

Metabolism

9 of 984

0.92

0.95

8.68e-06

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005749

Mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)

2 of 3

2.79

1.2

0.0067

GOCC:0098798

Mitochondrial protein complex

3 of 139

1.3

0.63

0.0407

GOCC:0005739

Mitochondrion

5 of 526

0.94

0.58

0.0196

GOCC:0005737

Cytoplasm

10 of 2476

0.57

0.42

0.0067

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0816

Tricarboxylic acid cycle

2 of 7

2.42

1.12

0.0087

KW-0830

Ubiquinone

2 of 9

2.31

1.11

0.0087

KW-0809

Transit peptide

2 of 14

2.12

1.07

0.0096

KW-0411

Iron-sulfur

2 of 20

1.96

0.97

0.0138

KW-0456

Lyase

2 of 40

1.66

0.71

0.0407

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00549

CoA-ligase

2 of 3

2.79

1.1

0.0100

PF00285

Citrate synthase, C-terminal domain

2 of 5

2.57

1.09

0.0105

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR017866

Succinyl-CoA synthetase, beta subunit, conserved site

2 of 2

2.96

0.98

0.0172

IPR016102

Succinyl-CoA synthetase-like

2 of 3

2.79

0.98

0.0172

IPR005811

ATP-citrate lyase/succinyl-CoA ligase

2 of 3

2.79

0.98

0.0172

IPR036969

Citrate synthase superfamily

2 of 5

2.57

0.97

0.0172

IPR016143

Citrate synthase-like, small alpha subdomain

2 of 5

2.57

0.97

0.0172

(more ...)

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