ANB38156.1 protein (Rhodovulum sulfidophilum)

Nodes:

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

Cooccurrence

Coexpression

Experiments

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[Homology]

Score

ANB38156.1

Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (195 aa)

Predicted Functional Partners:

ANB36785.1

0.989

ANB38157.1

0.985

ANB36784.1

0.977

ANB39625.1

0.976

ANB39626.1

0.975

ANB37037.1

0.968

FlgB

0.958

ANB39825.1

0.951

ANB37380.1

0.951

ANB37036.1

0.929

Your Current Organism:

Rhodovulum sulfidophilum

NCBI taxonomy Id: 35806
Other names: ATCC 35886, LMG 5201, LMG:5201, R. sulfidophilum, Rhodobacter sulfidiphilus, Rhodobacter sulfidophilus, Rhodopseudomonas sulfidophila, strain Hansen W4

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ANB36784.1	ANB36785.1	A6024_01850	A6024_01855	Anti-anti-sigma factor; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.999
ANB36784.1	ANB37036.1	A6024_01850	A6024_03285	Anti-anti-sigma factor; Derived by automated computational analysis using gene prediction method: Protein Homology.	Fused response regulator/phosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.929
ANB36784.1	ANB37037.1	A6024_01850	A6024_03290	Anti-anti-sigma factor; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.850
ANB36784.1	ANB37380.1	A6024_01850	A6024_05245	Anti-anti-sigma factor; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.520
ANB36784.1	ANB38156.1	A6024_01850	A6024_09600	Anti-anti-sigma factor; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.977
ANB36784.1	ANB38157.1	A6024_01850	A6024_09605	Anti-anti-sigma factor; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.591
ANB36784.1	ANB39625.1	A6024_01850	A6024_17930	Anti-anti-sigma factor; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.972
ANB36784.1	ANB39825.1	A6024_01850	A6024_01600	Anti-anti-sigma factor; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.952
ANB36784.1	FlgB	A6024_01850	A6024_01565	Anti-anti-sigma factor; Derived by automated computational analysis using gene prediction method: Protein Homology.	Flagellar biosynthesis protein FlgB; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.951
ANB36785.1	ANB36784.1	A6024_01855	A6024_01850	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	Anti-anti-sigma factor; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.999
ANB36785.1	ANB37036.1	A6024_01855	A6024_03285	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	Fused response regulator/phosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.933
ANB36785.1	ANB37037.1	A6024_01855	A6024_03290	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.989
ANB36785.1	ANB37380.1	A6024_01855	A6024_05245	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.756
ANB36785.1	ANB38156.1	A6024_01855	A6024_09600	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.989
ANB36785.1	ANB38157.1	A6024_01855	A6024_09605	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.714
ANB36785.1	ANB39625.1	A6024_01855	A6024_17930	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.992
ANB36785.1	ANB39626.1	A6024_01855	A6024_17935	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.997
ANB36785.1	ANB39825.1	A6024_01855	A6024_01600	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.951
ANB36785.1	FlgB	A6024_01855	A6024_01565	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	Flagellar biosynthesis protein FlgB; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.958
ANB37036.1	ANB36784.1	A6024_03285	A6024_01850	Fused response regulator/phosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Anti-anti-sigma factor; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.929

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Network Stats

number of nodes:

11

number of edges:

53

average node degree:

9.64

avg. local clustering coefficient:

0.968

expected number of edges:

33

PPI enrichment p-value:

0.000683

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0018106

Peptidyl-histidine phosphorylation

6 of 25

1.88

3.02

8.67e-08

GO:0007165

Signal transduction

6 of 58

1.51

1.99

2.83e-06

GO:0050896

Response to stimulus

11 of 236

1.17

1.71

2.41e-10

GO:0000160

Phosphorelay signal transduction system

3 of 46

1.31

0.69

0.0287

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0004673

Protein histidine kinase activity

7 of 26

1.93

3.76

7.90e-10

GO:0016772

Transferase activity, transferring phosphorus-containing groups

9 of 143

1.3

1.96

4.11e-09

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016021

Integral component of membrane

9 of 671

0.63

0.49

0.0019

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:3210

PAS-associated, C-terminal, and cheY-homologous receiver domain

10 of 15

2.32

7.99

3.66e-19

CL:3213

Signal transduction histidine kinase, dimerisation/phosphoacceptor domain, and Cell pole

8 of 10

2.4

6.93

1.56e-15

CL:3205

Signal transduction, and PAS fold-4

11 of 34

2.01

6.46

3.66e-19

CL:3216

PAS-associated, C-terminal, and WD40/YVTN repeat-like-containing domain superfamily

5 of 5

2.5

4.5

1.57e-09

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map02020

Two-component system

10 of 255

1.09

1.44

7.16e-09

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0597

Phosphoprotein

9 of 46

1.79

4.18

3.52e-13

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR011006

CheY-like superfamily

9 of 37

1.88

4.53

3.88e-13

IPR001789

Signal transduction response regulator, receiver domain

9 of 37

1.88

4.53

3.88e-13

IPR003661

Signal transduction histidine kinase, dimerisation/phosphoacceptor domain

7 of 21

2.02

4.21

1.40e-10

IPR036097

Signal transduction histidine kinase, dimerisation/phosphoacceptor domain superfamily

7 of 22

2.0

4.16

1.40e-10

IPR005467

Histidine kinase domain

7 of 24

1.96

4.03

1.85e-10

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00448

cheY-homologous receiver domain

9 of 35

1.91

4.91

2.15e-14

SM00388

His Kinase A (phosphoacceptor) domain

7 of 22

2.0

4.4

2.37e-11

SM00387

Histidine kinase-like ATPases

7 of 26

1.93

4.13

4.31e-11

SM00091

PAS domain

3 of 10

1.98

1.84

0.00019

SM00086

Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain)

2 of 5

2.1

1.24

0.0043

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