STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
uvrAExcinuclease ABC subunit A; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate. (952 aa)    
Predicted Functional Partners:
uvrB
Excinuclease ABC subunit B; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate [...]
 
 0.995
UvrC
Excinuclease ABC subunit C; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
 
 0.911
Mfd
Transcription-repair coupling factor; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
 
 
 0.911
recA
Hypothetical protein; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family.
 
  
 0.785
ANB39975.1
Repressor LexA; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
  
 0.708
ANB36994.1
Glutamate synthase subunit alpha; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
   
 0.683
PolA
DNA polymerase I; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
   
 0.644
ANB39314.1
DNA helicase II; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
 
 0.644
TopA
DNA topoisomerase I; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
  
 0.560
ANB38582.1
Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.
       0.535
Your Current Organism:
Rhodovulum sulfidophilum
NCBI taxonomy Id: 35806
Other names: ATCC 35886, LMG 5201, LMG:5201, R. sulfidophilum, Rhodobacter sulfidiphilus, Rhodobacter sulfidophilus, Rhodopseudomonas sulfidophila, strain Hansen W4
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