STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
kynATryptophan 2,3-dioxygenase; Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L- tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety. (279 aa)    
Predicted Functional Partners:
kynU
Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively.
 
 
 0.995
kynB
Arylformamidase; Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation.
 
 
 0.994
AOB34464.1
Esterase; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
 
 0.926
trpA
Tryptophan synthase subunit alpha; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family.
     
 0.808
trpB
Tryptophan synthase subunit beta; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine.
     
 0.807
AOB34472.1
Catalyzes the conversion of salicylyl-CoA to gentisyl-CoA; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
  
 0.601
hppD
4-hydroxyphenylpyruvate dioxygenase; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
  
 0.565
AOB34476.1
2-aminobenzoate-CoA ligase; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
    0.491
AOB36965.1
Cyclase; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
  
 0.487
AOB37047.1
Cyclase; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
  
 0.487
Your Current Organism:
Bordetella holmesii
NCBI taxonomy Id: 35814
Other names: ATCC 51541, B. holmesii, CCUG 34073, CDC F5101, CDC nonoxidizer group 2 (NO-2), CIP 104394, DSM 13416, LMG 15945, LMG:15945, NCTC 12912
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