node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
KPH50882.1 | KPH51245.1 | HPU229336_00530 | HPU229336_09345 | Pyruvate ferredoxin oxidoreductase; Catalyzes the formation of acetyl-CoA from pyruvate and coenzyme A; Derived by automated computational analysis using gene prediction method: Protein Homology. | Pyruvate carboxylase subunit B; Catalyzes the formation of oxaloacetate from pyruvate; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.916 |
KPH50882.1 | ilvH | HPU229336_00530 | HPU229336_00995 | Pyruvate ferredoxin oxidoreductase; Catalyzes the formation of acetyl-CoA from pyruvate and coenzyme A; Derived by automated computational analysis using gene prediction method: Protein Homology. | Acetolactate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.870 |
KPH50882.1 | leuA | HPU229336_00530 | HPU229336_01420 | Pyruvate ferredoxin oxidoreductase; Catalyzes the formation of acetyl-CoA from pyruvate and coenzyme A; Derived by automated computational analysis using gene prediction method: Protein Homology. | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. | 0.880 |
KPH50882.1 | leuC | HPU229336_00530 | HPU229336_06520 | Pyruvate ferredoxin oxidoreductase; Catalyzes the formation of acetyl-CoA from pyruvate and coenzyme A; Derived by automated computational analysis using gene prediction method: Protein Homology. | 3-isopropylmalate dehydratase; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. | 0.868 |
KPH50882.1 | leuD | HPU229336_00530 | HPU229336_01380 | Pyruvate ferredoxin oxidoreductase; Catalyzes the formation of acetyl-CoA from pyruvate and coenzyme A; Derived by automated computational analysis using gene prediction method: Protein Homology. | 3-isopropylmalate dehydratase; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 2 subfamily. | 0.868 |
KPH50882.1 | porA_3 | HPU229336_00530 | HPU229336_00525 | Pyruvate ferredoxin oxidoreductase; Catalyzes the formation of acetyl-CoA from pyruvate and coenzyme A; Derived by automated computational analysis using gene prediction method: Protein Homology. | 2-ketoisovalerate ferredoxin oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.999 |
KPH50882.1 | ppsA | HPU229336_00530 | HPU229336_05430 | Pyruvate ferredoxin oxidoreductase; Catalyzes the formation of acetyl-CoA from pyruvate and coenzyme A; Derived by automated computational analysis using gene prediction method: Protein Homology. | Phosphoenolpyruvate synthase; Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate; Belongs to the PEP-utilizing enzyme family. | 0.880 |
KPH51245.1 | KPH50882.1 | HPU229336_09345 | HPU229336_00530 | Pyruvate carboxylase subunit B; Catalyzes the formation of oxaloacetate from pyruvate; Derived by automated computational analysis using gene prediction method: Protein Homology. | Pyruvate ferredoxin oxidoreductase; Catalyzes the formation of acetyl-CoA from pyruvate and coenzyme A; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.916 |
KPH51245.1 | ilvH | HPU229336_09345 | HPU229336_00995 | Pyruvate carboxylase subunit B; Catalyzes the formation of oxaloacetate from pyruvate; Derived by automated computational analysis using gene prediction method: Protein Homology. | Acetolactate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.827 |
KPH51245.1 | leuA | HPU229336_09345 | HPU229336_01420 | Pyruvate carboxylase subunit B; Catalyzes the formation of oxaloacetate from pyruvate; Derived by automated computational analysis using gene prediction method: Protein Homology. | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. | 0.852 |
KPH51245.1 | leuD | HPU229336_09345 | HPU229336_01380 | Pyruvate carboxylase subunit B; Catalyzes the formation of oxaloacetate from pyruvate; Derived by automated computational analysis using gene prediction method: Protein Homology. | 3-isopropylmalate dehydratase; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 2 subfamily. | 0.886 |
KPH51245.1 | oorB | HPU229336_09345 | HPU229336_05590 | Pyruvate carboxylase subunit B; Catalyzes the formation of oxaloacetate from pyruvate; Derived by automated computational analysis using gene prediction method: Protein Homology. | 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Catalyzes the coenzyme A-dependent formation of succinyl-CoA from 2-oxoglutarate and ferredoxin; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.916 |
KPH51245.1 | porA_3 | HPU229336_09345 | HPU229336_00525 | Pyruvate carboxylase subunit B; Catalyzes the formation of oxaloacetate from pyruvate; Derived by automated computational analysis using gene prediction method: Protein Homology. | 2-ketoisovalerate ferredoxin oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.911 |
KPH51245.1 | ppsA | HPU229336_09345 | HPU229336_05430 | Pyruvate carboxylase subunit B; Catalyzes the formation of oxaloacetate from pyruvate; Derived by automated computational analysis using gene prediction method: Protein Homology. | Phosphoenolpyruvate synthase; Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate; Belongs to the PEP-utilizing enzyme family. | 0.936 |
ilvC | ilvH | HPU229336_02245 | HPU229336_00995 | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | Acetolactate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.997 |
ilvC | leuA | HPU229336_02245 | HPU229336_01420 | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. | 0.920 |
ilvC | leuB | HPU229336_02245 | HPU229336_01385 | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. | 0.911 |
ilvC | leuC | HPU229336_02245 | HPU229336_06520 | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 3-isopropylmalate dehydratase; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. | 0.919 |
ilvC | leuD | HPU229336_02245 | HPU229336_01380 | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 3-isopropylmalate dehydratase; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 2 subfamily. | 0.917 |
ilvH | KPH50882.1 | HPU229336_00995 | HPU229336_00530 | Acetolactate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Pyruvate ferredoxin oxidoreductase; Catalyzes the formation of acetyl-CoA from pyruvate and coenzyme A; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.870 |