node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AFU45508.1 | AFU46079.1 | C380_09030 | C380_11890 | 5'-nucleotidase domain-containing protein; COG0737 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases; Belongs to the 5'-nucleotidase family. | COG1011 Predicted hydrolase (HAD superfamily). | 0.905 |
AFU45508.1 | AFU47695.1 | C380_09030 | C380_20005 | 5'-nucleotidase domain-containing protein; COG0737 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases; Belongs to the 5'-nucleotidase family. | 5-nucleotidase; COG0468 RecA/RadA recombinase. | 0.900 |
AFU45508.1 | apt | C380_09030 | C380_23865 | 5'-nucleotidase domain-containing protein; COG0737 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases; Belongs to the 5'-nucleotidase family. | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | 0.914 |
AFU45508.1 | gmk | C380_09030 | C380_04945 | 5'-nucleotidase domain-containing protein; COG0737 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases; Belongs to the 5'-nucleotidase family. | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | 0.902 |
AFU45508.1 | guaA | C380_09030 | C380_14650 | 5'-nucleotidase domain-containing protein; COG0737 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases; Belongs to the 5'-nucleotidase family. | GMP synthase; Catalyzes the synthesis of GMP from XMP. | 0.919 |
AFU45508.1 | guaB | C380_09030 | C380_14665 | 5'-nucleotidase domain-containing protein; COG0737 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases; Belongs to the 5'-nucleotidase family. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.920 |
AFU45508.1 | guaC | C380_09030 | C380_06840 | 5'-nucleotidase domain-containing protein; COG0737 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases; Belongs to the 5'-nucleotidase family. | Guanosine 5'-monophosphate oxidoreductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides; Belongs to the IMPDH/GMPR family. GuaC type 2 subfamily. | 0.907 |
AFU45508.1 | purA | C380_09030 | C380_08450 | 5'-nucleotidase domain-containing protein; COG0737 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases; Belongs to the 5'-nucleotidase family. | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | 0.914 |
AFU45508.1 | purH | C380_09030 | C380_19705 | 5'-nucleotidase domain-containing protein; COG0737 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases; Belongs to the 5'-nucleotidase family. | Bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; COG0138 AICAR transformylase/IMP cyclohydrolase PurH (only IMP cyclohydrolase domain in Aful). | 0.909 |
AFU45508.1 | surE | C380_09030 | C380_08340 | 5'-nucleotidase domain-containing protein; COG0737 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases; Belongs to the 5'-nucleotidase family. | 5'(3')-nucleotidase/polyphosphatase; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. | 0.917 |
AFU46079.1 | AFU45508.1 | C380_11890 | C380_09030 | COG1011 Predicted hydrolase (HAD superfamily). | 5'-nucleotidase domain-containing protein; COG0737 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases; Belongs to the 5'-nucleotidase family. | 0.905 |
AFU46079.1 | AFU47695.1 | C380_11890 | C380_20005 | COG1011 Predicted hydrolase (HAD superfamily). | 5-nucleotidase; COG0468 RecA/RadA recombinase. | 0.900 |
AFU46079.1 | apt | C380_11890 | C380_23865 | COG1011 Predicted hydrolase (HAD superfamily). | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | 0.907 |
AFU46079.1 | gmk | C380_11890 | C380_04945 | COG1011 Predicted hydrolase (HAD superfamily). | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | 0.900 |
AFU46079.1 | guaA | C380_11890 | C380_14650 | COG1011 Predicted hydrolase (HAD superfamily). | GMP synthase; Catalyzes the synthesis of GMP from XMP. | 0.917 |
AFU46079.1 | guaB | C380_11890 | C380_14665 | COG1011 Predicted hydrolase (HAD superfamily). | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.916 |
AFU46079.1 | guaC | C380_11890 | C380_06840 | COG1011 Predicted hydrolase (HAD superfamily). | Guanosine 5'-monophosphate oxidoreductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides; Belongs to the IMPDH/GMPR family. GuaC type 2 subfamily. | 0.913 |
AFU46079.1 | purA | C380_11890 | C380_08450 | COG1011 Predicted hydrolase (HAD superfamily). | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | 0.909 |
AFU46079.1 | purH | C380_11890 | C380_19705 | COG1011 Predicted hydrolase (HAD superfamily). | Bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; COG0138 AICAR transformylase/IMP cyclohydrolase PurH (only IMP cyclohydrolase domain in Aful). | 0.904 |
AFU46079.1 | surE | C380_11890 | C380_08340 | COG1011 Predicted hydrolase (HAD superfamily). | 5'(3')-nucleotidase/polyphosphatase; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. | 0.907 |