node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
B4167_0011 | FolP | B4167_0011 | B4167_0014 | DNA-binding protein. | Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. | 0.617 |
B4167_0011 | folB | B4167_0011 | B4167_0013 | DNA-binding protein. | Dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. | 0.544 |
B4167_0011 | folK | B4167_0011 | B4167_0012 | DNA-binding protein. | 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase. | 0.818 |
B4167_0815 | B4167_0843 | B4167_0815 | B4167_0843 | Nucleoside 5-triphosphatase RdgB (dHAPTP, dITP, XTP-specific); Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | Dihydrofolate synthase / Folylpolyglutamate synthase; Belongs to the folylpolyglutamate synthase family. | 0.476 |
B4167_0815 | FolP | B4167_0815 | B4167_0014 | Nucleoside 5-triphosphatase RdgB (dHAPTP, dITP, XTP-specific); Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. | 0.584 |
B4167_0815 | RibD | B4167_0815 | B4167_1076 | Nucleoside 5-triphosphatase RdgB (dHAPTP, dITP, XTP-specific); Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | Diaminohydroxyphosphoribosylaminopyrimidine deaminase; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | 0.500 |
B4167_0815 | folB | B4167_0815 | B4167_0013 | Nucleoside 5-triphosphatase RdgB (dHAPTP, dITP, XTP-specific); Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | Dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. | 0.560 |
B4167_0815 | folE | B4167_0815 | B4167_0613 | Nucleoside 5-triphosphatase RdgB (dHAPTP, dITP, XTP-specific); Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | GTP cyclohydrolase I type 1. | 0.615 |
B4167_0815 | folK | B4167_0815 | B4167_0012 | Nucleoside 5-triphosphatase RdgB (dHAPTP, dITP, XTP-specific); Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase. | 0.592 |
B4167_0843 | B4167_0815 | B4167_0843 | B4167_0815 | Dihydrofolate synthase / Folylpolyglutamate synthase; Belongs to the folylpolyglutamate synthase family. | Nucleoside 5-triphosphatase RdgB (dHAPTP, dITP, XTP-specific); Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 0.476 |
B4167_0843 | B4167_2798 | B4167_0843 | B4167_2798 | Dihydrofolate synthase / Folylpolyglutamate synthase; Belongs to the folylpolyglutamate synthase family. | Hypothetical protein. | 0.514 |
B4167_0843 | FolP | B4167_0843 | B4167_0014 | Dihydrofolate synthase / Folylpolyglutamate synthase; Belongs to the folylpolyglutamate synthase family. | Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. | 0.997 |
B4167_0843 | RibD | B4167_0843 | B4167_1076 | Dihydrofolate synthase / Folylpolyglutamate synthase; Belongs to the folylpolyglutamate synthase family. | Diaminohydroxyphosphoribosylaminopyrimidine deaminase; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | 0.549 |
B4167_0843 | folB | B4167_0843 | B4167_0013 | Dihydrofolate synthase / Folylpolyglutamate synthase; Belongs to the folylpolyglutamate synthase family. | Dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. | 0.635 |
B4167_0843 | folE | B4167_0843 | B4167_0613 | Dihydrofolate synthase / Folylpolyglutamate synthase; Belongs to the folylpolyglutamate synthase family. | GTP cyclohydrolase I type 1. | 0.635 |
B4167_0843 | folK | B4167_0843 | B4167_0012 | Dihydrofolate synthase / Folylpolyglutamate synthase; Belongs to the folylpolyglutamate synthase family. | 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase. | 0.686 |
B4167_2798 | B4167_0843 | B4167_2798 | B4167_0843 | Hypothetical protein. | Dihydrofolate synthase / Folylpolyglutamate synthase; Belongs to the folylpolyglutamate synthase family. | 0.514 |
B4167_2798 | FolP | B4167_2798 | B4167_0014 | Hypothetical protein. | Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. | 0.685 |
B4167_2798 | RibD | B4167_2798 | B4167_1076 | Hypothetical protein. | Diaminohydroxyphosphoribosylaminopyrimidine deaminase; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | 0.587 |
B4167_2798 | birA | B4167_2798 | B4167_0590 | Hypothetical protein. | Biotin-protein ligase; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a repressor; Belongs to the biotin--protein ligase family. | 0.591 |