STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
sigBRNA polymerase sigma-B factor; Belongs to the sigma-70 factor family. (262 aa)    
Predicted Functional Partners:
rsbV
anti-sigma-B factor antagonist; Belongs to the anti-sigma-factor antagonist family.
 
 
 0.998
rsbW
Serine-protein kinase; Negative regulator of sigma-B activity. Phosphorylates and inactivates its specific antagonist protein, RsbV. Upon phosphorylation of RsbV, RsbW is released and binds to sigma-B, thereby blocking its ability to form an RNA polymerase holoenzyme (E-sigma-B).
 
 
 0.998
rsbU
Phosphoserine phosphatase.
 
 
 0.948
rsbT
Serine/threonine-protein kinase.
 
 
 0.905
flgM
Negative regulator of flagellin synthesis.
  
 
 0.882
fliY
Flagellar motor switch protein FliY.
  
  
 0.840
spoIIAA
anti-sigma-F factor antagonist; Belongs to the anti-sigma-factor antagonist family.
 
  
 0.838
BAH46256.1
Hypothetical protein; Required for flagellar hook formation. May act as a scaffolding protein.
 
  
 0.786
spoIIAB
anti-sigma-F factor; Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti- anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition.
 
 
 0.773
flgB
Flagellar basal-body rod protein FlgB; Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body.
  
 
 0.768
Your Current Organism:
Brevibacillus brevis
NCBI taxonomy Id: 358681
Other names: B. brevis NBRC 100599, Brevibacillus brevis NBRC 100599, Brevibacillus brevis str. NBRC 100599, Brevibacillus brevis strain NBRC 100599
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.