node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
BAH43181.1 | BAH43722.1 | BBR47_22040 | BBR47_27450 | Putative 5,10-methylenetetrahydrofolate reductase. | Probable serine hydroxymethyltransferase. | 0.957 |
BAH43181.1 | fhs | BBR47_22040 | BBR47_56450 | Putative 5,10-methylenetetrahydrofolate reductase. | Probable formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | 0.958 |
BAH43181.1 | fmt | BBR47_22040 | BBR47_37290 | Putative 5,10-methylenetetrahydrofolate reductase. | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | 0.946 |
BAH43181.1 | folD | BBR47_22040 | BBR47_23370 | Putative 5,10-methylenetetrahydrofolate reductase. | Probable methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.952 |
BAH43181.1 | gcvT | BBR47_22040 | BBR47_22970 | Putative 5,10-methylenetetrahydrofolate reductase. | Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine. | 0.964 |
BAH43181.1 | glyA | BBR47_22040 | BBR47_54690 | Putative 5,10-methylenetetrahydrofolate reductase. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.957 |
BAH43181.1 | purH | BBR47_22040 | BBR47_06060 | Putative 5,10-methylenetetrahydrofolate reductase. | Phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase. | 0.949 |
BAH43181.1 | purN | BBR47_22040 | BBR47_06030 | Putative 5,10-methylenetetrahydrofolate reductase. | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.947 |
BAH43181.1 | purU | BBR47_22040 | BBR47_49590 | Putative 5,10-methylenetetrahydrofolate reductase. | Formyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). | 0.948 |
BAH43722.1 | BAH43181.1 | BBR47_27450 | BBR47_22040 | Probable serine hydroxymethyltransferase. | Putative 5,10-methylenetetrahydrofolate reductase. | 0.957 |
BAH43722.1 | fhs | BBR47_27450 | BBR47_56450 | Probable serine hydroxymethyltransferase. | Probable formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | 0.954 |
BAH43722.1 | fmt | BBR47_27450 | BBR47_37290 | Probable serine hydroxymethyltransferase. | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | 0.918 |
BAH43722.1 | folD | BBR47_27450 | BBR47_23370 | Probable serine hydroxymethyltransferase. | Probable methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.975 |
BAH43722.1 | gcvT | BBR47_27450 | BBR47_22970 | Probable serine hydroxymethyltransferase. | Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine. | 0.996 |
BAH43722.1 | glyA | BBR47_27450 | BBR47_54690 | Probable serine hydroxymethyltransferase. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.925 |
BAH43722.1 | purH | BBR47_27450 | BBR47_06060 | Probable serine hydroxymethyltransferase. | Phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase. | 0.984 |
BAH43722.1 | purN | BBR47_27450 | BBR47_06030 | Probable serine hydroxymethyltransferase. | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.966 |
BAH43722.1 | purU | BBR47_27450 | BBR47_49590 | Probable serine hydroxymethyltransferase. | Formyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). | 0.928 |
fhs | BAH43181.1 | BBR47_56450 | BBR47_22040 | Probable formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | Putative 5,10-methylenetetrahydrofolate reductase. | 0.958 |
fhs | BAH43722.1 | BBR47_56450 | BBR47_27450 | Probable formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | Probable serine hydroxymethyltransferase. | 0.954 |