node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CN09_03380 | CN09_03985 | CN09_03380 | CN09_03985 | 2-oxoisovalerate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology | Anthranilate synthase; trpE(G); catalyzes the formation of anthranilate from chorismate and glutamine; contains both component I and II; Derived by automated computational analysis using gene prediction method: Protein Homology | 0.999 |
CN09_03380 | gcvP | CN09_03380 | CN09_06885 | 2-oxoisovalerate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology | Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein | 0.890 |
CN09_03380 | guaB | CN09_03380 | CN09_16005 | 2-oxoisovalerate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology | inosine-5-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth | 0.999 |
CN09_03380 | polA | CN09_03380 | CN09_13050 | 2-oxoisovalerate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology | In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity | 0.627 |
CN09_03380 | ribD | CN09_03380 | CN09_10375 | 2-oxoisovalerate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology | 5-amino-6-(5-phosphoribosylamino)uracil reductase; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate | 0.999 |
CN09_03380 | rnhB | CN09_03380 | CN09_16450 | 2-oxoisovalerate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology | Ribonuclease hii; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids | 0.999 |
CN09_03380 | thyA | CN09_03380 | CN09_05290 | 2-oxoisovalerate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis | 0.934 |
CN09_03985 | CN09_03380 | CN09_03985 | CN09_03380 | Anthranilate synthase; trpE(G); catalyzes the formation of anthranilate from chorismate and glutamine; contains both component I and II; Derived by automated computational analysis using gene prediction method: Protein Homology | 2-oxoisovalerate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology | 0.999 |
CN09_03985 | gcvP | CN09_03985 | CN09_06885 | Anthranilate synthase; trpE(G); catalyzes the formation of anthranilate from chorismate and glutamine; contains both component I and II; Derived by automated computational analysis using gene prediction method: Protein Homology | Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein | 0.878 |
CN09_03985 | guaB | CN09_03985 | CN09_16005 | Anthranilate synthase; trpE(G); catalyzes the formation of anthranilate from chorismate and glutamine; contains both component I and II; Derived by automated computational analysis using gene prediction method: Protein Homology | inosine-5-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth | 0.444 |
CN09_03985 | polA | CN09_03985 | CN09_13050 | Anthranilate synthase; trpE(G); catalyzes the formation of anthranilate from chorismate and glutamine; contains both component I and II; Derived by automated computational analysis using gene prediction method: Protein Homology | In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity | 0.999 |
CN09_03985 | ribD | CN09_03985 | CN09_10375 | Anthranilate synthase; trpE(G); catalyzes the formation of anthranilate from chorismate and glutamine; contains both component I and II; Derived by automated computational analysis using gene prediction method: Protein Homology | 5-amino-6-(5-phosphoribosylamino)uracil reductase; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate | 0.999 |
CN09_03985 | rnhB | CN09_03985 | CN09_16450 | Anthranilate synthase; trpE(G); catalyzes the formation of anthranilate from chorismate and glutamine; contains both component I and II; Derived by automated computational analysis using gene prediction method: Protein Homology | Ribonuclease hii; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids | 0.439 |
CN09_03985 | thyA | CN09_03985 | CN09_05290 | Anthranilate synthase; trpE(G); catalyzes the formation of anthranilate from chorismate and glutamine; contains both component I and II; Derived by automated computational analysis using gene prediction method: Protein Homology | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis | 0.999 |
CN09_05380 | dut | CN09_05380 | CN09_14245 | Diacylglycerol kinase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis | Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA | 0.503 |
CN09_05380 | gcvP | CN09_05380 | CN09_06885 | Diacylglycerol kinase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis | Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein | 0.771 |
CN09_05380 | polA | CN09_05380 | CN09_13050 | Diacylglycerol kinase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis | In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity | 0.457 |
CN09_05380 | ribD | CN09_05380 | CN09_10375 | Diacylglycerol kinase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis | 5-amino-6-(5-phosphoribosylamino)uracil reductase; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate | 0.999 |
CN09_05380 | thyA | CN09_05380 | CN09_05290 | Diacylglycerol kinase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis | 0.999 |
dut | CN09_05380 | CN09_14245 | CN09_05380 | Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA | Diacylglycerol kinase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis | 0.503 |