node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CN09_07710 | cbiE | CN09_07710 | CN09_23625 | Siroheme synthase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme | Precorrin-6Y methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology | 0.999 |
CN09_07710 | cobB | CN09_07710 | CN09_05865 | Siroheme synthase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme | Cobyrinic acid a,c-diamide synthase; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of hydrogenobyrinate, using either L- glutamine or ammonia as the nitrogen source | 0.999 |
CN09_07710 | cobD | CN09_07710 | CN09_05875 | Siroheme synthase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme | Cobalamin biosynthesis protein cobd; Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group | 0.999 |
CN09_07710 | cobN | CN09_07710 | CN09_05820 | Siroheme synthase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme | Cobalamin biosynthesis protein CobN; Derived by automated computational analysis using gene prediction method: Protein Homology | 0.999 |
CN09_07710 | cobO | CN09_07710 | CN09_05830 | Siroheme synthase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme | Cobinamide adenolsyltransferase; Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids | 0.999 |
CN09_07710 | cobQ | CN09_07710 | CN09_05795 | Siroheme synthase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme | Cobalamin biosynthesis protein cobq; Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation | 0.999 |
CN09_07710 | cobS | CN09_07710 | CN09_06075 | Siroheme synthase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme | Cobalamin synthase; Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'- phosphate | 0.999 |
CN09_07710 | cobU | CN09_07710 | CN09_05810 | Siroheme synthase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme | Cobalamin biosynthesis protein; Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate | 0.999 |
CN09_07710 | metH | CN09_07710 | CN09_04750 | Siroheme synthase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate | 0.962 |
cbiE | CN09_07710 | CN09_23625 | CN09_07710 | Precorrin-6Y methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology | Siroheme synthase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme | 0.999 |
cbiE | cobB | CN09_23625 | CN09_05865 | Precorrin-6Y methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology | Cobyrinic acid a,c-diamide synthase; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of hydrogenobyrinate, using either L- glutamine or ammonia as the nitrogen source | 0.999 |
cbiE | cobD | CN09_23625 | CN09_05875 | Precorrin-6Y methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology | Cobalamin biosynthesis protein cobd; Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group | 0.999 |
cbiE | cobN | CN09_23625 | CN09_05820 | Precorrin-6Y methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology | Cobalamin biosynthesis protein CobN; Derived by automated computational analysis using gene prediction method: Protein Homology | 0.999 |
cbiE | cobO | CN09_23625 | CN09_05830 | Precorrin-6Y methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology | Cobinamide adenolsyltransferase; Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids | 0.999 |
cbiE | cobQ | CN09_23625 | CN09_05795 | Precorrin-6Y methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology | Cobalamin biosynthesis protein cobq; Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation | 0.999 |
cbiE | cobS | CN09_23625 | CN09_06075 | Precorrin-6Y methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology | Cobalamin synthase; Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'- phosphate | 0.999 |
cbiE | cobU | CN09_23625 | CN09_05810 | Precorrin-6Y methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology | Cobalamin biosynthesis protein; Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate | 0.999 |
cbiE | cobW | CN09_23625 | CN09_05815 | Precorrin-6Y methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology | Cobalamin biosynthesis protein CobW; Derived by automated computational analysis using gene prediction method: Protein Homology | 0.887 |
cbiE | metH | CN09_23625 | CN09_04750 | Precorrin-6Y methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate | 0.999 |
cobB | CN09_07710 | CN09_05865 | CN09_07710 | Cobyrinic acid a,c-diamide synthase; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of hydrogenobyrinate, using either L- glutamine or ammonia as the nitrogen source | Siroheme synthase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme | 0.999 |