node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CN09_01860 | CN09_17085 | CN09_01860 | CN09_17085 | D-arabinose 5-phosphate; Belongs to the SIS family. GutQ/KpsF subfamily | Pyruvate phosphate dikinase; Belongs to the PEP-utilizing enzyme family | 0.999 |
CN09_01860 | engB | CN09_01860 | CN09_14825 | D-arabinose 5-phosphate; Belongs to the SIS family. GutQ/KpsF subfamily | Gtp-binding protein; Necessary for normal cell division and for the maintenance of normal septation | 0.821 |
CN09_01860 | guaB | CN09_01860 | CN09_16005 | D-arabinose 5-phosphate; Belongs to the SIS family. GutQ/KpsF subfamily | inosine-5-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth | 0.931 |
CN09_01860 | ispDF | CN09_01860 | CN09_07765 | D-arabinose 5-phosphate; Belongs to the SIS family. GutQ/KpsF subfamily | 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase; Bifunctional enzyme that catalyzes the formation of 4- diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D- erythritol 4-phosphate (MEP) (IspD), and catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C- methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (IspF) | 0.918 |
CN09_01860 | macB | CN09_01860 | CN09_25550 | D-arabinose 5-phosphate; Belongs to the SIS family. GutQ/KpsF subfamily | Non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides | 0.432 |
CN09_01860 | ttcA | CN09_01860 | CN09_06600 | D-arabinose 5-phosphate; Belongs to the SIS family. GutQ/KpsF subfamily | Trna 2-thiocytidine biosynthesis protein ttca; Catalyzes the ATP-dependent 2-thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32). The sulfur atoms are provided by the cysteine/cysteine desulfurase (IscS) system | 0.816 |
CN09_06610 | ispDF | CN09_06610 | CN09_07765 | Inositol-1-monophosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the inositol monophosphatase superfamily | 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase; Bifunctional enzyme that catalyzes the formation of 4- diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D- erythritol 4-phosphate (MEP) (IspD), and catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C- methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (IspF) | 0.424 |
CN09_06610 | rpsD | CN09_06610 | CN09_06590 | Inositol-1-monophosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the inositol monophosphatase superfamily | 30S ribosomal protein S4; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit | 0.624 |
CN09_06610 | ttcA | CN09_06610 | CN09_06600 | Inositol-1-monophosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the inositol monophosphatase superfamily | Trna 2-thiocytidine biosynthesis protein ttca; Catalyzes the ATP-dependent 2-thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32). The sulfur atoms are provided by the cysteine/cysteine desulfurase (IscS) system | 0.816 |
CN09_07710 | engB | CN09_07710 | CN09_14825 | Siroheme synthase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme | Gtp-binding protein; Necessary for normal cell division and for the maintenance of normal septation | 0.732 |
CN09_07710 | ispDF | CN09_07710 | CN09_07765 | Siroheme synthase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme | 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase; Bifunctional enzyme that catalyzes the formation of 4- diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D- erythritol 4-phosphate (MEP) (IspD), and catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C- methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (IspF) | 0.999 |
CN09_07710 | ttcA | CN09_07710 | CN09_06600 | Siroheme synthase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme | Trna 2-thiocytidine biosynthesis protein ttca; Catalyzes the ATP-dependent 2-thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32). The sulfur atoms are provided by the cysteine/cysteine desulfurase (IscS) system | 0.792 |
CN09_17085 | CN09_01860 | CN09_17085 | CN09_01860 | Pyruvate phosphate dikinase; Belongs to the PEP-utilizing enzyme family | D-arabinose 5-phosphate; Belongs to the SIS family. GutQ/KpsF subfamily | 0.999 |
CN09_17085 | guaB | CN09_17085 | CN09_16005 | Pyruvate phosphate dikinase; Belongs to the PEP-utilizing enzyme family | inosine-5-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth | 0.908 |
CN09_17085 | ispDF | CN09_17085 | CN09_07765 | Pyruvate phosphate dikinase; Belongs to the PEP-utilizing enzyme family | 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase; Bifunctional enzyme that catalyzes the formation of 4- diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D- erythritol 4-phosphate (MEP) (IspD), and catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C- methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (IspF) | 0.997 |
CN09_17085 | rnpA | CN09_17085 | CN09_14845 | Pyruvate phosphate dikinase; Belongs to the PEP-utilizing enzyme family | Ribonuclease p; RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme | 0.636 |
CN09_17085 | ttcA | CN09_17085 | CN09_06600 | Pyruvate phosphate dikinase; Belongs to the PEP-utilizing enzyme family | Trna 2-thiocytidine biosynthesis protein ttca; Catalyzes the ATP-dependent 2-thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32). The sulfur atoms are provided by the cysteine/cysteine desulfurase (IscS) system | 0.809 |
engB | CN09_01860 | CN09_14825 | CN09_01860 | Gtp-binding protein; Necessary for normal cell division and for the maintenance of normal septation | D-arabinose 5-phosphate; Belongs to the SIS family. GutQ/KpsF subfamily | 0.821 |
engB | CN09_07710 | CN09_14825 | CN09_07710 | Gtp-binding protein; Necessary for normal cell division and for the maintenance of normal septation | Siroheme synthase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme | 0.732 |
engB | rnpA | CN09_14825 | CN09_14845 | Gtp-binding protein; Necessary for normal cell division and for the maintenance of normal septation | Ribonuclease p; RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme | 0.999 |