node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CN09_07185 | CN09_07710 | CN09_07185 | CN09_07710 | Nickel transporter; Belongs to the NiCoT transporter (TC 2.A.52) family | Siroheme synthase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme | 0.999 |
CN09_07185 | CN09_23620 | CN09_07185 | CN09_23620 | Nickel transporter; Belongs to the NiCoT transporter (TC 2.A.52) family | Cobalt-precorrin-6X reductase; Derived by automated computational analysis using gene prediction method: Protein Homology | 0.697 |
CN09_07185 | cbiE | CN09_07185 | CN09_23625 | Nickel transporter; Belongs to the NiCoT transporter (TC 2.A.52) family | Precorrin-6Y methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology | 0.999 |
CN09_07185 | cobM | CN09_07185 | CN09_23630 | Nickel transporter; Belongs to the NiCoT transporter (TC 2.A.52) family | precorrin-4 C11-methyltransferase; Belongs to the precorrin methyltransferase family | 0.685 |
CN09_07185 | cobN | CN09_07185 | CN09_05820 | Nickel transporter; Belongs to the NiCoT transporter (TC 2.A.52) family | Cobalamin biosynthesis protein CobN; Derived by automated computational analysis using gene prediction method: Protein Homology | 0.686 |
CN09_07185 | cobW | CN09_07185 | CN09_05815 | Nickel transporter; Belongs to the NiCoT transporter (TC 2.A.52) family | Cobalamin biosynthesis protein CobW; Derived by automated computational analysis using gene prediction method: Protein Homology | 0.696 |
CN09_07185 | ureC | CN09_07185 | CN09_03115 | Nickel transporter; Belongs to the NiCoT transporter (TC 2.A.52) family | Urease subunit alpha; Ureases catalyze the hydrolysis of urea into ammonia and carbon dioxide; in Helicobacter pylori the ammonia released plays a key role in bacterial survival by neutralizing acids when colonizing the gastric mucosa; the holoenzyme is composed of 3 ureC (alpha) and 3 ureAB (gamma/beta) subunits; Derived by automated computational analysis using gene prediction method: Protein Homology | 0.709 |
CN09_07185 | ureD | CN09_07185 | CN09_03095 | Nickel transporter; Belongs to the NiCoT transporter (TC 2.A.52) family | Urease accessory protein ured; Required for maturation of urease via the functional incorporation of the urease nickel metallocenter | 0.743 |
CN09_07185 | ureE | CN09_07185 | CN09_03130 | Nickel transporter; Belongs to the NiCoT transporter (TC 2.A.52) family | Urease accessory protein uree; Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly | 0.743 |
CN09_07185 | ureF | CN09_07185 | CN09_03135 | Nickel transporter; Belongs to the NiCoT transporter (TC 2.A.52) family | Urease accessory protein uref; Required for maturation of urease via the functional incorporation of the urease nickel metallocenter | 0.710 |
CN09_07710 | CN09_07185 | CN09_07710 | CN09_07185 | Siroheme synthase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme | Nickel transporter; Belongs to the NiCoT transporter (TC 2.A.52) family | 0.999 |
CN09_07710 | CN09_23620 | CN09_07710 | CN09_23620 | Siroheme synthase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme | Cobalt-precorrin-6X reductase; Derived by automated computational analysis using gene prediction method: Protein Homology | 0.999 |
CN09_07710 | cbiE | CN09_07710 | CN09_23625 | Siroheme synthase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme | Precorrin-6Y methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology | 0.999 |
CN09_07710 | cobM | CN09_07710 | CN09_23630 | Siroheme synthase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme | precorrin-4 C11-methyltransferase; Belongs to the precorrin methyltransferase family | 0.999 |
CN09_07710 | cobN | CN09_07710 | CN09_05820 | Siroheme synthase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme | Cobalamin biosynthesis protein CobN; Derived by automated computational analysis using gene prediction method: Protein Homology | 0.999 |
CN09_23620 | CN09_07185 | CN09_23620 | CN09_07185 | Cobalt-precorrin-6X reductase; Derived by automated computational analysis using gene prediction method: Protein Homology | Nickel transporter; Belongs to the NiCoT transporter (TC 2.A.52) family | 0.697 |
CN09_23620 | CN09_07710 | CN09_23620 | CN09_07710 | Cobalt-precorrin-6X reductase; Derived by automated computational analysis using gene prediction method: Protein Homology | Siroheme synthase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme | 0.999 |
CN09_23620 | cbiE | CN09_23620 | CN09_23625 | Cobalt-precorrin-6X reductase; Derived by automated computational analysis using gene prediction method: Protein Homology | Precorrin-6Y methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology | 0.999 |
CN09_23620 | cobM | CN09_23620 | CN09_23630 | Cobalt-precorrin-6X reductase; Derived by automated computational analysis using gene prediction method: Protein Homology | precorrin-4 C11-methyltransferase; Belongs to the precorrin methyltransferase family | 0.998 |
CN09_23620 | cobN | CN09_23620 | CN09_05820 | Cobalt-precorrin-6X reductase; Derived by automated computational analysis using gene prediction method: Protein Homology | Cobalamin biosynthesis protein CobN; Derived by automated computational analysis using gene prediction method: Protein Homology | 0.928 |