STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CN09_07185Nickel transporter; Belongs to the NiCoT transporter (TC 2.A.52) family (349 aa)    
Predicted Functional Partners:
CN09_07710
Siroheme synthase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
  
    0.999
cbiE
Precorrin-6Y methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology
       0.999
ureD
Urease accessory protein ured; Required for maturation of urease via the functional incorporation of the urease nickel metallocenter
     
 0.743
ureE
Urease accessory protein uree; Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
     
 0.743
ureF
Urease accessory protein uref; Required for maturation of urease via the functional incorporation of the urease nickel metallocenter
     
 0.710
ureC
Urease subunit alpha; Ureases catalyze the hydrolysis of urea into ammonia and carbon dioxide; in Helicobacter pylori the ammonia released plays a key role in bacterial survival by neutralizing acids when colonizing the gastric mucosa; the holoenzyme is composed of 3 ureC (alpha) and 3 ureAB (gamma/beta) subunits; Derived by automated computational analysis using gene prediction method: Protein Homology
     
 0.709
CN09_23620
Cobalt-precorrin-6X reductase; Derived by automated computational analysis using gene prediction method: Protein Homology
 
     0.697
cobW
Cobalamin biosynthesis protein CobW; Derived by automated computational analysis using gene prediction method: Protein Homology
     
 0.696
cobN
Cobalamin biosynthesis protein CobN; Derived by automated computational analysis using gene prediction method: Protein Homology
     
 0.686
cobM
precorrin-4 C11-methyltransferase; Belongs to the precorrin methyltransferase family
 
     0.685
Your Current Organism:
Agrobacterium rhizogenes
NCBI taxonomy Id: 359
Other names: A. rhizogenes, ATCC 11325, Agrobacterium biovar 2, Agrobacterium genomic group 10, Agrobacterium genomic species 10, Agrobacterium genomosp. 10, Agrobacterium rhizogenes (RI plasmid PRI1724), Agrobacterium rhizogenes (RI plasmid PRI8196), Agrobacterium rhizogenes (RI plasmid PRIA4B), CFBP 5520, CIP 104328, DSM 30148, ICMP 5794, IFO 13257, JCM 20919, LMG 150, NBRC 13257, NCPPB 2991, Rhizobium rhizogenes, Rhizobium sp. LMG 9509
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