node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CN09_27055 | CN09_27060 | CN09_27055 | CN09_27060 | Hypothetical protein; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter | Molecular chaperone groel; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions | 0.999 |
CN09_27055 | groL | CN09_27055 | CN09_16220 | Hypothetical protein; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter | Molecular chaperone groel; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions | 0.999 |
CN09_27055 | grpE | CN09_27055 | CN09_14485 | Hypothetical protein; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter | Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions be [...] | 0.899 |
CN09_27055 | guaA | CN09_27055 | CN09_14055 | Hypothetical protein; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter | Gmp synthase; Catalyzes the synthesis of GMP from XMP | 0.898 |
CN09_27055 | guaB | CN09_27055 | CN09_16005 | Hypothetical protein; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter | inosine-5-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth | 0.894 |
CN09_27055 | htpG | CN09_27055 | CN09_32535 | Hypothetical protein; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter | Heat shock protein 90; Molecular chaperone. Has ATPase activity | 0.878 |
CN09_27055 | nnrD | CN09_27055 | CN09_07485 | Hypothetical protein; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter | Hypothetical protein; Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epim [...] | 0.955 |
CN09_27055 | rplL | CN09_27055 | CN09_08940 | Hypothetical protein; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter | 50S ribosomal protein L7; Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation | 0.880 |
CN09_27055 | rpsQ | CN09_27055 | CN09_08850 | Hypothetical protein; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter | Small subunit ribosomal protein s17; One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA | 0.846 |
CN09_27055 | tsaE | CN09_27055 | CN09_17560 | Hypothetical protein; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter | Chlorosome protein; Derived by automated computational analysis using gene prediction method: Protein Homology | 0.915 |
CN09_27060 | CN09_27055 | CN09_27060 | CN09_27055 | Molecular chaperone groel; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions | Hypothetical protein; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter | 0.999 |
CN09_27060 | grpE | CN09_27060 | CN09_14485 | Molecular chaperone groel; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions | Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions be [...] | 0.996 |
CN09_27060 | guaA | CN09_27060 | CN09_14055 | Molecular chaperone groel; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions | Gmp synthase; Catalyzes the synthesis of GMP from XMP | 0.928 |
CN09_27060 | guaB | CN09_27060 | CN09_16005 | Molecular chaperone groel; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions | inosine-5-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth | 0.993 |
CN09_27060 | htpG | CN09_27060 | CN09_32535 | Molecular chaperone groel; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions | Heat shock protein 90; Molecular chaperone. Has ATPase activity | 0.977 |
CN09_27060 | nnrD | CN09_27060 | CN09_07485 | Molecular chaperone groel; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions | Hypothetical protein; Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epim [...] | 0.716 |
CN09_27060 | rplL | CN09_27060 | CN09_08940 | Molecular chaperone groel; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions | 50S ribosomal protein L7; Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation | 0.703 |
CN09_27060 | tsaE | CN09_27060 | CN09_17560 | Molecular chaperone groel; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions | Chlorosome protein; Derived by automated computational analysis using gene prediction method: Protein Homology | 0.972 |
groL | CN09_27055 | CN09_16220 | CN09_27055 | Molecular chaperone groel; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions | Hypothetical protein; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter | 0.999 |
groL | grpE | CN09_16220 | CN09_14485 | Molecular chaperone groel; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions | Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions be [...] | 0.996 |