STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ureC-1Urease:Amidohydrolase; May protect brucellae during their passage through the stomach. The major route of infection in human brucellosis is oral; Belongs to the metallo-dependent hydrolases superfamily. Urease alpha subunit family. (570 aa)    
Predicted Functional Partners:
ureA-1
Urease, gamma subunit; Disruption of the ure1 gene cluster suggests that it protects brucellae during their passage through the stomach. The major route of infection in human brucellosis is oral.
 0.999
ureB-1
Urease, beta subunit; Disruption of the ure1 gene cluster suggests that it protects brucellae during their passage through the stomach. The major route of infection in human brucellosis is oral.
 0.999
ureB2
Urease, beta subunit; Disrupting the ure2 operon has no effect on urease activity or pathogen survival in BALB/c mice when administered orally.
 0.999
ureA-2
Urease, gamma subunit; Disrupting the ure2 operon has no effect on urease activity or pathogen survival in BALB/c mice when administered orally.
 
 0.993
ureG-1
Urease accessory protein UreG 1; Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG; Belongs to the SIMIBI class G3E GTPase family. UreG subfamily.
  
 0.982
ureF1
Urease accessory protein UreF; Required for maturation of urease via the functional incorporation of the urease nickel metallocenter; Belongs to the UreF family.
 
 
 0.980
ureE1
UreE urease accessory, N-terminal:UreE urease accessory, C-terminal; Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly.
 
  
 0.978
ureF2
UreE urease accessory, N-terminal; Required for maturation of urease via the functional incorporation of the urease nickel metallocenter; Belongs to the UreF family.
 
 
 0.944
ureG2
Urease accessory protein UreG 2; Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG.
  
 0.931
ureD-1
Urease accessory protein UreD; Required for maturation of urease via the functional incorporation of the urease nickel metallocenter; Belongs to the UreD family.
 
  
 0.843
Your Current Organism:
Brucella abortus
NCBI taxonomy Id: 359391
Other names: B. abortus 2308, Brucella abortus 2308, Brucella melitensis biovar Abortus 2308
Server load: low (22%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.