STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
BAB2_0057Outer membrane protein OprF; The virB operon is essential for intracellular survival and is not involved in the invasion process. Constitutes a major determinant of virulence in mice. This protein is essential for pathogenesis in mice but is not required for intracellular survival. (172 aa)    
Predicted Functional Partners:
tolB
TolB, N-terminal; Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity.
  
 0.895
guaA
GMP synthase [glutamine-hydrolyzing]; Catalyzes the synthesis of GMP from XMP.
  
 
  0.764
ribB
3,4-Dihydroxy-2-butanone 4-phosphate synthase:GTP cyclohydrolase II; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; Belongs to the DHBP synthase family.
    
  0.667
virB10
Glutelin:Proline-rich region:Bacterial conjugation TrbI-like protein; The virB operon is essential for intracellular survival and is not involved in the invasion process. Constitutes a major determinant of virulence in mice. Virb10 seems to be per se essential for intracellular multiplication within non-professional phagocytes and is essential for pathogenesis in mice.
   
   0.651
BAB1_0633
Cytochrome c assembly protein:Cytochrome c-type biogenesis protein:Cytochrome c-type biogenesis protein CcmF.
  
 
 0.648
secDF
Protein translocase subunit SecDF; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity); In the C-terminal section; belongs to the SecD/SecF family. SecF subfamily.
  
  
 0.603
secF
Protein-export membrane protein SecF; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA; Belongs to the SecD/SecF family. SecD subfamily.
  
  
 0.603
secA
SecA protein:ATP/GTP-binding site motif A (P-loop):SEC-C motif; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane. Belongs to the SecA family.
    
 0.600
BAB1_0346
Na+/solute symporter:Response regulator receiver:ATP-binding region, ATPase-like:Histidine kinase A, N-terminal:Bacterial sen.
  
 
 0.544
rpsF
Ribosomal protein S6; Binds together with S18 to 16S ribosomal RNA.
  
   0.528
Your Current Organism:
Brucella abortus
NCBI taxonomy Id: 359391
Other names: B. abortus 2308, Brucella abortus 2308, Brucella melitensis biovar Abortus 2308
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