STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
coaBCCoenzyme A biosynthesis bifunctional protein CoaBC; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. (406 aa)    
Predicted Functional Partners:
dut
Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family.
 
 
 0.983
coaD
Coenzyme A biosynthesis protein:Cytidylyltransferase:Cytidyltransferase-related domain; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family.
 
 
 0.971
coaA
Uridine kinase:ATP/GTP-binding site motif A (P-loop):Bacterial pantothenate kinase:Phosphoribulokinase/uridine kinase.
  
 
 0.924
BAB1_1089
ATP/GTP-binding site motif A (P-loop):MazG family protein.
     
  0.894
panC
Pantoate-beta-alanine ligase:Cytidyltransferase-related domain; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family.
 
  
 0.865
ubiB
Protein kinase:ABC1 protein; Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis. Belongs to the ABC1 family. UbiB subfamily.
 
  
 0.815
BAB1_2160
S-adenosylmethionine synthetase; Belongs to the AdoMet synthase family.
   0.793
aspC
Aminotransferase; 1-aminocyclopropane-1-carboxylate synthase:Aminotransferase, class-I:Aminotransferase, class I and II.
  
  0.768
BAB1_1073
Cysteine synthase/cystathionine beta-synthase P-phosphate attachment site:Pyridoxal-5'-phosphate-dependent enzyme, beta family.
    
  0.754
BAB1_1968
ATP/GTP-binding site motif A (P-loop):Pyridoxal-5'-phosphate-dependent enzyme, beta family:Glucose/ribitol dehydrogenase:Cyst.
    
  0.754
Your Current Organism:
Brucella abortus
NCBI taxonomy Id: 359391
Other names: B. abortus 2308, Brucella abortus 2308, Brucella melitensis biovar Abortus 2308
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