| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| BON22_0029 | BON22_0139 | A0A1V2LED9 | A0A061AVC1 | Elongator complex protein 3. | Elongator complex protein 1; Component of the RNA polymerase II elongator complex, a multiprotein complex associated with the RNA polymerase II (Pol II) holoenzyme, and which is involved in transcriptional elongation. Belongs to the ELP1/IKA1 family. | 0.997 |
| BON22_0029 | BON22_0214 | A0A1V2LED9 | A0A1V2LBV4 | Elongator complex protein 3. | Histone acetyltransferase GCN5. | 0.969 |
| BON22_0029 | BON22_1376 | A0A1V2LED9 | A0A1V2LAD9 | Elongator complex protein 3. | Elongator complex protein 2. | 0.994 |
| BON22_0029 | BON22_2186 | A0A1V2LED9 | A0A1V2LAB2 | Elongator complex protein 3. | Elongator complex protein 4. | 0.997 |
| BON22_0029 | BON22_2465 | A0A1V2LED9 | A0A1V2L8U2 | Elongator complex protein 3. | Casein kinase I hhp1; Belongs to the protein kinase superfamily. | 0.955 |
| BON22_0029 | BON22_2931 | A0A1V2LED9 | A0A1V2L7I0 | Elongator complex protein 3. | Protein kti12. | 0.985 |
| BON22_0029 | BON22_4107 | A0A1V2LED9 | A0A061AT15 | Elongator complex protein 3. | Diphthamide biosynthesis protein 3. | 0.984 |
| BON22_0029 | BON22_4960 | A0A1V2LED9 | A0A061BEN2 | Elongator complex protein 3. | Elongator complex protein 5. | 0.995 |
| BON22_0029 | UBA4 | A0A1V2LED9 | A0A1V2L4M1 | Elongator complex protein 3. | Adenylyltransferase and sulfurtransferase UBA4; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Acts by mediating the C-terminal thiocarboxylation of sulfur carrier URM1. Its N-terminus first activates URM1 as acyl-adenylate (-COAMP), then the persulfide sulfur on the catalytic cysteine is transferred to URM1 to form thiocarboxylation (-COSH) of its C-terminus. The reaction probably involves hydrogen sulfide that is generated from the persulfide intermediate and that acts as nucleophile towards URM1. Subseque [...] | 0.935 |
| BON22_0029 | URM1 | A0A1V2LED9 | A0A1V2KZR9 | Elongator complex protein 3. | Ubiquitin-related modifier 1; Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2-thiolation reaction by being thiocarboxylated (-COSH) at its C-terminus by the MOCS3 homolog UBA4. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target pr [...] | 0.948 |
| BON22_0139 | BON22_0029 | A0A061AVC1 | A0A1V2LED9 | Elongator complex protein 1; Component of the RNA polymerase II elongator complex, a multiprotein complex associated with the RNA polymerase II (Pol II) holoenzyme, and which is involved in transcriptional elongation. Belongs to the ELP1/IKA1 family. | Elongator complex protein 3. | 0.997 |
| BON22_0139 | BON22_0214 | A0A061AVC1 | A0A1V2LBV4 | Elongator complex protein 1; Component of the RNA polymerase II elongator complex, a multiprotein complex associated with the RNA polymerase II (Pol II) holoenzyme, and which is involved in transcriptional elongation. Belongs to the ELP1/IKA1 family. | Histone acetyltransferase GCN5. | 0.545 |
| BON22_0139 | BON22_1376 | A0A061AVC1 | A0A1V2LAD9 | Elongator complex protein 1; Component of the RNA polymerase II elongator complex, a multiprotein complex associated with the RNA polymerase II (Pol II) holoenzyme, and which is involved in transcriptional elongation. Belongs to the ELP1/IKA1 family. | Elongator complex protein 2. | 0.994 |
| BON22_0139 | BON22_2186 | A0A061AVC1 | A0A1V2LAB2 | Elongator complex protein 1; Component of the RNA polymerase II elongator complex, a multiprotein complex associated with the RNA polymerase II (Pol II) holoenzyme, and which is involved in transcriptional elongation. Belongs to the ELP1/IKA1 family. | Elongator complex protein 4. | 0.996 |
| BON22_0139 | BON22_2465 | A0A061AVC1 | A0A1V2L8U2 | Elongator complex protein 1; Component of the RNA polymerase II elongator complex, a multiprotein complex associated with the RNA polymerase II (Pol II) holoenzyme, and which is involved in transcriptional elongation. Belongs to the ELP1/IKA1 family. | Casein kinase I hhp1; Belongs to the protein kinase superfamily. | 0.962 |
| BON22_0139 | BON22_2931 | A0A061AVC1 | A0A1V2L7I0 | Elongator complex protein 1; Component of the RNA polymerase II elongator complex, a multiprotein complex associated with the RNA polymerase II (Pol II) holoenzyme, and which is involved in transcriptional elongation. Belongs to the ELP1/IKA1 family. | Protein kti12. | 0.984 |
| BON22_0139 | BON22_4107 | A0A061AVC1 | A0A061AT15 | Elongator complex protein 1; Component of the RNA polymerase II elongator complex, a multiprotein complex associated with the RNA polymerase II (Pol II) holoenzyme, and which is involved in transcriptional elongation. Belongs to the ELP1/IKA1 family. | Diphthamide biosynthesis protein 3. | 0.971 |
| BON22_0139 | BON22_4960 | A0A061AVC1 | A0A061BEN2 | Elongator complex protein 1; Component of the RNA polymerase II elongator complex, a multiprotein complex associated with the RNA polymerase II (Pol II) holoenzyme, and which is involved in transcriptional elongation. Belongs to the ELP1/IKA1 family. | Elongator complex protein 5. | 0.995 |
| BON22_0139 | UBA4 | A0A061AVC1 | A0A1V2L4M1 | Elongator complex protein 1; Component of the RNA polymerase II elongator complex, a multiprotein complex associated with the RNA polymerase II (Pol II) holoenzyme, and which is involved in transcriptional elongation. Belongs to the ELP1/IKA1 family. | Adenylyltransferase and sulfurtransferase UBA4; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Acts by mediating the C-terminal thiocarboxylation of sulfur carrier URM1. Its N-terminus first activates URM1 as acyl-adenylate (-COAMP), then the persulfide sulfur on the catalytic cysteine is transferred to URM1 to form thiocarboxylation (-COSH) of its C-terminus. The reaction probably involves hydrogen sulfide that is generated from the persulfide intermediate and that acts as nucleophile towards URM1. Subseque [...] | 0.933 |
| BON22_0139 | URM1 | A0A061AVC1 | A0A1V2KZR9 | Elongator complex protein 1; Component of the RNA polymerase II elongator complex, a multiprotein complex associated with the RNA polymerase II (Pol II) holoenzyme, and which is involved in transcriptional elongation. Belongs to the ELP1/IKA1 family. | Ubiquitin-related modifier 1; Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2-thiolation reaction by being thiocarboxylated (-COSH) at its C-terminus by the MOCS3 homolog UBA4. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target pr [...] | 0.816 |
