STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
lon-2ATP-dependent protease La; ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short- lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner. (865 aa)    
Predicted Functional Partners:
GAP12676.1
Protein containg AAA ATPase domain.
   
 0.859
grpE
Molecular chaperone GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP [...]
  
  
 0.858
groL
Chaperonin GroL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions.
  
 
 0.855
GAP12370.1
Trypsin-like serine protease, typically periplasmic, contain C-terminal PDZ domain.
    
 0.846
GAP12891.1
Trypsin-like serine protease, typically periplasmic, contain C-terminal PDZ domain.
    
 0.846
GAP13313.1
Trypsin-like serine protease, typically periplasmic, contain C-terminal PDZ domain.
    
 0.846
GAP14369.1
Trypsin-like serine protease, typically periplasmic, contain C-terminal PDZ domain.
    
 0.846
GAP14621.1
Trypsin-like serine protease, typically periplasmic, contain C-terminal PDZ domain.
    
 0.846
GAP14659.1
Trypsin-like serine protease, typically periplasmic, contain C-terminal PDZ domain.
    
 0.846
htpG
Molecular chaperone, HSP90 family; Molecular chaperone. Has ATPase activity.
   
  
 0.844
Your Current Organism:
Longilinea arvoryzae
NCBI taxonomy Id: 360412
Other names: JCM 13670, KTCC 5380, L. arvoryzae, Longilinea arvoryzae Yamada et al. 2007, anaerobic filamentous bacterium KOME-1, strain KOME-1
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