STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
ilvCKetol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (338 aa)    
Predicted Functional Partners:
ilvH
Acetolactate synthase isozyme III small subunit.
 
 
 0.999
ilvI1
Acetolactate synthase isozyme III large subunit; Also similar to BAV3387 (46.528 38d).
 
 
 0.996
ilvI2
Acetolactate synthase isozyme III large subunit; Also similar to BAV2673 (46.528 38d).
 
 
 0.987
ilvD
Dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family.
 
 
 0.977
BAV0961
Putative acetolactate synthase large subunit; Start codon not provided; Belongs to the TPP enzyme family.
 
 
 0.975
ilvG
Acetolactate synthase synthase isozyme II large subunit; Also similar to BAV0902 (52.585 38d.); Belongs to the TPP enzyme family.
 
 
 0.972
ilvB
Acetolactate synthase isozyme I large subunit; Also similar to BAV1880 (52.585 38d.); Belongs to the TPP enzyme family.
 
 
 0.968
BAV0899
Putative decarboxylase.
 
 
 0.958
leuC1
3-isopropylmalate dehydratase large subunit.
 
  
 0.886
leuD1
3-isopropylmalate dehydratase small subunit; Belongs to the LeuD family.
 
  
 0.843
Your Current Organism:
Bordetella avium
NCBI taxonomy Id: 360910
Other names: B. avium 197N, Bordetella avium 197N, Bordetella avium str. 197N, Bordetella avium strain 197N
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