STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
icd-2Isocitrate dehydrogenase [NADP]. (418 aa)    
Predicted Functional Partners:
fumA
Putative fumarate hydratase; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family.
  
  
 0.982
acnB
Aconitate hydratase 2; Belongs to the aconitase/IPM isomerase family.
  
 
 0.981
sucA
2-oxoglutarate dehydrogenase E1 component.
   
 
 0.979
acnA1
Aconitate hydratase; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate.
 
 0.972
acnA2
Aconitate hydratase; Also similar to BAV2732 (41.8 38d.), BAV2514 (40.9 id) and BAV0625 (44.6 38d).
 
 0.972
acnA3
Putative lipoprotein (pseudogene); Catalyzes the isomerization of citrate to isocitrate via cis- aconitate.
  
 0.968
mdh
Malate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 2 family.
  
 
 0.936
sucC
Succinyl-CoA synthetase beta chain; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
  
  
 0.922
icd
Isocitrate dehydrogenase [NADP]; Belongs to the monomeric-type IDH family.
    
 0.920
gltB
Glutamate synthase [NADPH] large chain precursor.
    
 0.909
Your Current Organism:
Bordetella avium
NCBI taxonomy Id: 360910
Other names: B. avium 197N, Bordetella avium 197N, Bordetella avium str. 197N, Bordetella avium strain 197N
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.