STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
DLAC_07866Guanylate kinase-like domain-containing protein. (196 aa)    
Predicted Functional Partners:
DLAC_07814
Pleckstrin (PH) domain-containing protein.
   
 0.948
DLAC_05125
Leucine-rich repeat-containing protein (LRR).
   
 0.948
DLAC_06636
C2 domain-containing protein.
   
 0.937
DLAC_02409
RNA polymerase II core subunit.
  
  
 0.800
DLAC_02885
Adenine phosphoribosyltransferase.
  
 
 0.794
DLAC_06911
Ubiquitin-related modifier 1 homolog; Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2-thiolation reaction by being thiocarboxylated (-COSH) at its C-terminus by the MOCS3/UBA4 homolog. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target proteins. The thiocarboxylated form serves as substrate for conjugation and oxid [...]
   
 0.787
DLAC_03810
Phosphoribosylamine-glycine ligase.
  
 
 0.781
DLAC_09041
GMP synthetase.
  
 
 0.727
DLAC_02064
Glutamine amidotransferase class-I domain-containing protein.
  
 
 0.700
DLAC_11801
Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways.
   
 0.693
Your Current Organism:
Tieghemostelium lacteum
NCBI taxonomy Id: 361077
Other names: Dictyostelium lacteum, T. lacteum
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.