STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
DLAC_05305DNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks. (1252 aa)    
Predicted Functional Partners:
DLAC_06031
DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus r [...]
   
 
 0.924
DLAC_09718
Structural maintenance of chromosomes protein.
   
 
 0.785
DLAC_06177
Putative E2 enzyme Ubc9; Belongs to the ubiquitin-conjugating enzyme family.
   
 0.779
DLAC_02579
Condensin complex subunit 2; Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes.
   
 
 0.759
DLAC_04229
Ubiquitin-conjugating enzyme E2; Belongs to the ubiquitin-conjugating enzyme family.
   
 0.729
DLAC_07395
Structural maintenance of chromosome protein.
   
 
 0.728
DLAC_09401
tRNA(His) guanylyltransferase; Adds a GMP to the 5'-end of tRNA(His) after transcription and RNase P cleavage.
      
 0.714
DLAC_07825
Acetylglutamate kinase.
     
 0.701
DLAC_02026
Cytochrome b5 reductase.
     
 0.700
DLAC_11263
Tortoise.
      
 0.678
Your Current Organism:
Tieghemostelium lacteum
NCBI taxonomy Id: 361077
Other names: Dictyostelium lacteum, T. lacteum
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.