Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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Neighborhood
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Co-occurrence
Co-expression
Experiments
Databases
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[Homology]
Score
LSL_0022Hypothetical membrane spanning protein; COG0011 [S] Uncharacterized conserved protein. (448 aa)    
Predicted Functional Partners:
LSL_0023
Hypothetical protein.
       0.737
LSL_1710
COG0584 [C] Glycerophosphoryl diester phosphodiesterase.
 
     0.499
LSL_0680
ComE operon protein 3; COG2248 [R] Predicted hydrolase (metallo-beta-lactamase superfamily).
  
    0.462
glyA
Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
     
 0.462
tilS
tRNA(Ile)-lysidine synthase TilS; Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine.
  
    0.455
LSL_0070
COG2738 [R] Predicted Zn-dependent protease.
  
    0.448
LSL_0024
COG0697 [GER] Permeases of the drug/metabolite transporter (DMT) superfamily.
       0.444
LSL_0615
16S rRNA m(5)C 967 methyltransferase; Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA.
       0.439
LSL_0021
COG4975 [G] Putative glucose uptake permease.
       0.430
LSL_1535
Hypothetical exported protein; COG5263 [R] FOG: Glucan-binding domain (YG repeat).
       0.425
Your Current Organism:
Lactobacillus salivarius
NCBI taxonomy Id: 362948
Other names: L. salivarius UCC118, Lactobacillus salivarius UCC118, Lactobacillus salivarius str. UCC118, Lactobacillus salivarius strain UCC118, Lactobacillus salivarius subsp. salivarius UCC118
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