Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
gshAGlutamate--cysteine ligase; COG2918 [H] Gamma-glutamylcysteine synthetase; Belongs to the glutamate--cysteine ligase type 1 family. (452 aa)    
Predicted Functional Partners:
ilvE
COG0115 [EH] Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase.
     
  0.900
metC
COG0626 [E] Cystathionine beta-lyases/cystathionine gamma-synthases.
     
 0.826
gdhA
COG0334 [E] Glutamate dehydrogenase/leucine dehydrogenase; Belongs to the Glu/Leu/Phe/Val dehydrogenases family.
     
 0.826
glnA
COG0174 [E] Glutamine synthetase.
     
 0.825
cysK
COG0031 [E] Cysteine synthase.
     
 0.823
cysK-2
COG0031 [E] Cysteine synthase; Belongs to the cysteine synthase/cystathionine beta- synthase family.
     
 0.823
LSL_0204
Aminotransferase class I and II; COG1168 [E] Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities.
     
  0.800
purQ
Phosphoribosylformylglycinamidine synthase I; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist i [...]
    
  0.800
LSL_1499
Aminotransferase; COG1168 [E] Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities.
     
  0.800
ffh
Signal recognition particle protein; Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Belongs to the GTP-binding SRP family. SRP54 subfamily.
  
    0.522
Your Current Organism:
Lactobacillus salivarius
NCBI taxonomy Id: 362948
Other names: L. salivarius UCC118, Lactobacillus salivarius UCC118, Lactobacillus salivarius str. UCC118, Lactobacillus salivarius strain UCC118, Lactobacillus salivarius subsp. salivarius UCC118
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