STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ilvECOG0115 [EH] Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase. (344 aa)    
Predicted Functional Partners:
gshA
Glutamate--cysteine ligase; COG2918 [H] Gamma-glutamylcysteine synthetase; Belongs to the glutamate--cysteine ligase type 1 family.
     
  0.900
thrA
COG0460 [E] Homoserine dehydrogenase.
  
 
 0.872
thrB
Homoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily.
  
 
 0.864
ldh
L-lactate dehydrogenase; Catalyzes the conversion of lactate to pyruvate. Belongs to the LDH/MDH superfamily. LDH family.
  
 0.833
LSL_1600
COG0039 [C] Malate/lactate dehydrogenases; Belongs to the LDH/MDH superfamily.
  
 0.833
LSL_0650
Lactate/malate dehydrogenase.
  
 0.820
glnP
Glutamine-binding protein / Glutamine transport system permease protein; COG0834 [ET] ABC-type amino acid transport/signal transduction systems, periplasmic component/domain.
  
 
 0.488
gdhA
COG0334 [E] Glutamate dehydrogenase/leucine dehydrogenase; Belongs to the Glu/Leu/Phe/Val dehydrogenases family.
  
  
 0.471
LSL_0014
Pyruvate oxidase; COG0028 [EH] Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase]; Belongs to the TPP enzyme family.
  
 
 0.452
LSL_0186
Acetolactate synthase; COG0028 [EH] Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase]; Belongs to the TPP enzyme family.
  
 
 0.452
Your Current Organism:
Lactobacillus salivarius
NCBI taxonomy Id: 362948
Other names: L. salivarius UCC118, Lactobacillus salivarius UCC118, Lactobacillus salivarius str. UCC118, Lactobacillus salivarius strain UCC118, Lactobacillus salivarius subsp. salivarius UCC118
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