Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
LSL_0393COG0718 [S] Uncharacterized protein conserved in bacteria. (77 aa)    
Predicted Functional Partners:
mprF
Hypothetical secreted protein; Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms.
       0.680
rfaG-4
COG0438 [M] Glycosyltransferase.
       0.632
rfaG-3
COG0438 [M] Glycosyltransferase.
       0.605
LSL_0394
Sulfatase family protein; COG1368 [M] Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily.
       0.603
LSL_1089
COG0344 [S] Predicted membrane protein.
  
     0.549
LSL_0340
Conserved hypothetical protein.
  
     0.517
LSL_0675
Hypothetical protein.
  
     0.517
LSL_1154
Conserved hypothetical protein.
  
     0.517
LSL_0480
Phosphotransferase enzyme family; COG0510 [M] Predicted choline kinase involved in LPS biosynthesis.
  
     0.505
LSL_0385
Conserved hypothetical protein.
 
     0.493
Your Current Organism:
Lactobacillus salivarius
NCBI taxonomy Id: 362948
Other names: L. salivarius UCC118, Lactobacillus salivarius UCC118, Lactobacillus salivarius str. UCC118, Lactobacillus salivarius strain UCC118, Lactobacillus salivarius subsp. salivarius UCC118
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