close STRING v12.5 is now available!
The next version of STRING is ready for use in your analyses: updated networks across STRING • newly available directed regulatory networks • a new typed view showing functional, physical, and regulatory edges in one network • new clustering options and cluster-based layouts • … and much more!
Explore STRING v12.5 →
STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
LSL_0399Conserved hypothetical protein; COG2761 [Q] Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis. (201 aa)    
Predicted Functional Partners:
arsC-3
Arsenate reductase; Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development- promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress. Belongs to the ArsC family. Spx subfamily.
  
 
 0.872
LSL_0941
RibT protein.
 
     0.680
LSL_0687
Hypothetical secreted protein; COG0718 [S] Uncharacterized protein conserved in bacteria.
  
     0.679
arsC
COG1393 [P] Arsenate reductase and related proteins, glutaredoxin family; Belongs to the ArsC family.
   
   0.658
LSL_0417
Conserved hypothetical protein; COG4768 [R] Uncharacterized protein containing a divergent version of the methyl-accepting chemotaxis-like domain.
  
     0.647
LSL_0396
Negative regulator of genetic competence mecA; Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis; Belongs to the MecA family.
  
  
 0.643
ezrA
Septation ring formation regulator; Negative regulator of FtsZ ring formation; modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization; Belongs to the EzrA family.
  
     0.602
mreD
COG1792 [M] Cell shape-determining protein.
  
     0.587
LSL_0367
Sigma-70 factor family protein.
  
     0.537
LSL_0037
Hypothetical membrane spanning protein; COG0718 [S] Uncharacterized protein conserved in bacteria.
  
     0.518
Your Current Organism:
Lactobacillus salivarius
NCBI taxonomy Id: 362948
Other names: L. salivarius UCC118, Lactobacillus salivarius UCC118, Lactobacillus salivarius str. UCC118, Lactobacillus salivarius strain UCC118, Lactobacillus salivarius subsp. salivarius UCC118
Server load: medium (44%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.