node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
LSL_0487 | coaE | LSL_0487 | LSL_0490 | COG0670 [R] Integral membrane protein, interacts with FtsH; Belongs to the BI1 family. | Dephospho-CoA kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. | 0.649 |
LSL_0487 | dnaB | LSL_0487 | LSL_0492 | COG0670 [R] Integral membrane protein, interacts with FtsH; Belongs to the BI1 family. | COG3611 [L] Replication initiation/membrane attachment protein. | 0.566 |
LSL_0487 | dnaI | LSL_0487 | LSL_0493 | COG0670 [R] Integral membrane protein, interacts with FtsH; Belongs to the BI1 family. | COG1484 [L] DNA replication protein. | 0.558 |
LSL_0487 | murC | LSL_0487 | LSL_0485 | COG0670 [R] Integral membrane protein, interacts with FtsH; Belongs to the BI1 family. | UDP-N-acetylmuramate--alanine ligase; Cell wall formation; Belongs to the MurCDEF family. | 0.710 |
LSL_0487 | nei | LSL_0487 | LSL_0489 | COG0670 [R] Integral membrane protein, interacts with FtsH; Belongs to the BI1 family. | Formamidopyrimidine-DNA glycosylase; Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. | 0.659 |
LSL_0487 | nrdR | LSL_0487 | LSL_0491 | COG0670 [R] Integral membrane protein, interacts with FtsH; Belongs to the BI1 family. | Putative regulatory protein; Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes; Belongs to the NrdR family. | 0.587 |
LSL_0487 | polA | LSL_0487 | LSL_0488 | COG0670 [R] Integral membrane protein, interacts with FtsH; Belongs to the BI1 family. | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity. | 0.749 |
coaE | LSL_0487 | LSL_0490 | LSL_0487 | Dephospho-CoA kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. | COG0670 [R] Integral membrane protein, interacts with FtsH; Belongs to the BI1 family. | 0.649 |
coaE | dnaB | LSL_0490 | LSL_0492 | Dephospho-CoA kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. | COG3611 [L] Replication initiation/membrane attachment protein. | 0.852 |
coaE | dnaI | LSL_0490 | LSL_0493 | Dephospho-CoA kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. | COG1484 [L] DNA replication protein. | 0.852 |
coaE | murC | LSL_0490 | LSL_0485 | Dephospho-CoA kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. | UDP-N-acetylmuramate--alanine ligase; Cell wall formation; Belongs to the MurCDEF family. | 0.650 |
coaE | nei | LSL_0490 | LSL_0489 | Dephospho-CoA kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. | Formamidopyrimidine-DNA glycosylase; Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. | 0.996 |
coaE | nrdR | LSL_0490 | LSL_0491 | Dephospho-CoA kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. | Putative regulatory protein; Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes; Belongs to the NrdR family. | 0.862 |
coaE | polA | LSL_0490 | LSL_0488 | Dephospho-CoA kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity. | 0.958 |
coaE | thrS | LSL_0490 | LSL_0494 | Dephospho-CoA kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. | Threonyl-tRNA synthetase; Catalyzes the attachment of threonine to tRNA(Thr) in a two- step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr). Also edits incorrectly charged L-seryl-tRNA(Thr). | 0.588 |
dnaB | LSL_0487 | LSL_0492 | LSL_0487 | COG3611 [L] Replication initiation/membrane attachment protein. | COG0670 [R] Integral membrane protein, interacts with FtsH; Belongs to the BI1 family. | 0.566 |
dnaB | coaE | LSL_0492 | LSL_0490 | COG3611 [L] Replication initiation/membrane attachment protein. | Dephospho-CoA kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. | 0.852 |
dnaB | dnaI | LSL_0492 | LSL_0493 | COG3611 [L] Replication initiation/membrane attachment protein. | COG1484 [L] DNA replication protein. | 0.972 |
dnaB | murC | LSL_0492 | LSL_0485 | COG3611 [L] Replication initiation/membrane attachment protein. | UDP-N-acetylmuramate--alanine ligase; Cell wall formation; Belongs to the MurCDEF family. | 0.663 |
dnaB | nei | LSL_0492 | LSL_0489 | COG3611 [L] Replication initiation/membrane attachment protein. | Formamidopyrimidine-DNA glycosylase; Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. | 0.913 |