Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
LSL_0499Hydrolase, haloacid dehalogenase-like family; COG2179 [R] Predicted hydrolase of the HAD superfamily. (179 aa)    
Predicted Functional Partners:
LSL_0500
GTP-binding protein; COG1160 [R] Predicted GTPases.
 
  
 0.925
LSL_0503
Conserved hypothetical protein, HD domain; COG1713 [H] Predicted HD superfamily hydrolase involved in NAD metabolism.
 
  
 0.902
LSL_0501
Conserved hypothetical protein; COG1534 [J] Predicted RNA-binding protein containing KH domain, possibly ribosomal protein.
  
  
 0.877
nadD
Nicotinate-nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).
  
    0.867
rsfS
Iojap-related protein; Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation.
  
    0.802
LSL_1551
Transcriptional regulator, LytR family; COG0583 [K] Transcriptional regulator.
  
     0.467
LSL_0680
ComE operon protein 3; COG2248 [R] Predicted hydrolase (metallo-beta-lactamase superfamily).
       0.439
LSL_0498
Transposase ISLasa4i, ISL3 family; COG0675 [L] Transposase and inactivated derivatives.
       0.433
rplT
LSU ribosomal protein L20P; Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit.
       0.415
tmcAL
Conserved hypothetical protein; Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of elongator tRNA(Met), using acetate and ATP as substrates. First activates an acetate ion to form acetyladenylate (Ac- AMP) and then transfers the acetyl group to tRNA to form ac(4)C34.
       0.415
Your Current Organism:
Lactobacillus salivarius
NCBI taxonomy Id: 362948
Other names: L. salivarius UCC118, Lactobacillus salivarius UCC118, Lactobacillus salivarius str. UCC118, Lactobacillus salivarius strain UCC118, Lactobacillus salivarius subsp. salivarius UCC118
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