Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
LSL_0522COG0745 [TK] Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain. (228 aa)    
Predicted Functional Partners:
csrS
COG0642 [T] Signal transduction histidine kinase.
 0.998
baeS-3
Two component system histidine kinase; COG0642 [T] Signal transduction histidine kinase.
 
 0.895
baeS-2
Two component system histidine kinase; COG0642 [T] Signal transduction histidine kinase.
 
 0.873
baeS-4
Two component system histidine kinase; COG0642 [T] Signal transduction histidine kinase.
 
 0.863
LSL_0036
Two-component sensor kinase yycG; COG0642 [T] Signal transduction histidine kinase.
 
 0.796
LSL_0839
Conserved hypothetical protein; COG0116 [L] Predicted N6-adenine-specific DNA methylase; Belongs to the methyltransferase superfamily.
     
 0.502
rpoC
DNA-directed RNA polymerase beta' chain; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
    
 
 0.494
rpoB
DNA-directed RNA polymerase beta chain; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
    
 
 0.493
rpoD
RNA polymerase sigma factor; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth.
   
 
 0.488
rpoA
DNA-directed RNA polymerase alpha chain; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
    
 
 0.481
Your Current Organism:
Lactobacillus salivarius
NCBI taxonomy Id: 362948
Other names: L. salivarius UCC118, Lactobacillus salivarius UCC118, Lactobacillus salivarius str. UCC118, Lactobacillus salivarius strain UCC118, Lactobacillus salivarius subsp. salivarius UCC118
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