Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
LSL_0683COG1577 [I] Mevalonate kinase. (355 aa)    
Predicted Functional Partners:
LSL_0684
COG3407 [I] Mevalonate pyrophosphate decarboxylase.
 
 0.999
eRG
COG1577 [I] Mevalonate kinase.
 
  
 0.998
fni
Isopentenyl-diphosphate delta-isomerase; Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP).
  
 0.997
LSL_0526
COG3425 [I] 3-hydroxy-3-methylglutaryl CoA synthase.
 
  
 0.927
LSL_0224
COG1257 [I] Hydroxymethylglutaryl-CoA reductase; Belongs to the HMG-CoA reductase family.
 
 
 0.684
dinG
ATP-dependent helicase, DinG family; 3'-5' exonuclease.
       0.633
thrB
Homoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily.
      
 0.599
LSL_0687
Hypothetical secreted protein; COG0718 [S] Uncharacterized protein conserved in bacteria.
 
     0.542
pheT
COG0072 [J] Phenylalanyl-tRNA synthetase beta subunit; Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily.
  
 
 0.463
LSL_0690
DNA replication protein dnaD; COG3935 [L] Putative primosome component and related proteins.
 
     0.428
Your Current Organism:
Lactobacillus salivarius
NCBI taxonomy Id: 362948
Other names: L. salivarius UCC118, Lactobacillus salivarius UCC118, Lactobacillus salivarius str. UCC118, Lactobacillus salivarius strain UCC118, Lactobacillus salivarius subsp. salivarius UCC118
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