Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
msrAPeptide methionine sulfoxide reductase; Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine. (172 aa)    
Predicted Functional Partners:
msrB
COG0229 [O] Conserved domain frequently associated with peptide methionine sulfoxide reductase.
 
 0.994
trxA
Thioredoxin; COG0526 [OC] Thiol-disulfide isomerase and thioredoxins.
   
 0.829
grxC
COG0695 [O] Glutaredoxin and related proteins.
  
 
 0.778
LSL_0693
Hypothetical membrane spanning protein; COG0011 [S] Uncharacterized conserved protein.
       0.757
nth
Endonuclease III; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate.
     
 0.610
LSL_0690
DNA replication protein dnaD; COG3935 [L] Putative primosome component and related proteins.
       0.574
polA
DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity.
     
 0.552
LSL_1234
Hypothetical membrane spanning protein; COG0011 [S] Uncharacterized conserved protein.
     
 0.535
LSL_0694
Galactofuranosyltransferase.
  
    0.522
rfaG-5
Glycosyltransferase; COG3774 [M] Mannosyltransferase OCH1 and related enzymes.
       0.518
Your Current Organism:
Lactobacillus salivarius
NCBI taxonomy Id: 362948
Other names: L. salivarius UCC118, Lactobacillus salivarius UCC118, Lactobacillus salivarius str. UCC118, Lactobacillus salivarius strain UCC118, Lactobacillus salivarius subsp. salivarius UCC118
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