| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| LSL_0707 | dapB | LSL_0707 | LSL_0705 | ABC transporter, ATP-binding protein; COG0488 [R] ATPase components of ABC transporters with duplicated ATPase domains. | Dihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate. | 0.787 |
| LSL_0707 | folA | LSL_0707 | LSL_0709 | ABC transporter, ATP-binding protein; COG0488 [R] ATPase components of ABC transporters with duplicated ATPase domains. | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | 0.735 |
| LSL_0707 | pcnB | LSL_0707 | LSL_0706 | ABC transporter, ATP-binding protein; COG0488 [R] ATPase components of ABC transporters with duplicated ATPase domains. | Poly(A) polymerase / tRNA nucleotidyltransferase; Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate. | 0.797 |
| LSL_0707 | rplC | LSL_0707 | LSL_1435 | ABC transporter, ATP-binding protein; COG0488 [R] ATPase components of ABC transporters with duplicated ATPase domains. | LSU ribosomal protein L3P; One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit; Belongs to the universal ribosomal protein uL3 family. | 0.648 |
| LSL_0707 | rplD | LSL_0707 | LSL_1434 | ABC transporter, ATP-binding protein; COG0488 [R] ATPase components of ABC transporters with duplicated ATPase domains. | LSU ribosomal protein L1E; One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome. | 0.669 |
| LSL_0707 | rplM | LSL_0707 | LSL_1403 | ABC transporter, ATP-binding protein; COG0488 [R] ATPase components of ABC transporters with duplicated ATPase domains. | LSU ribosomal protein L13P; This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly. | 0.655 |
| LSL_0707 | rplU | LSL_0707 | LSL_0956 | ABC transporter, ATP-binding protein; COG0488 [R] ATPase components of ABC transporters with duplicated ATPase domains. | LSU ribosomal protein L21P; This protein binds to 23S rRNA in the presence of protein L20; Belongs to the bacterial ribosomal protein bL21 family. | 0.659 |
| LSL_0707 | rpsC | LSL_0707 | LSL_1429 | ABC transporter, ATP-binding protein; COG0488 [R] ATPase components of ABC transporters with duplicated ATPase domains. | SSU ribosomal protein S3P; Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation; Belongs to the universal ribosomal protein uS3 family. | 0.654 |
| LSL_0707 | rpsO | LSL_0707 | LSL_0638 | ABC transporter, ATP-binding protein; COG0488 [R] ATPase components of ABC transporters with duplicated ATPase domains. | SSU ribosomal protein S15P; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA. | 0.655 |
| LSL_0707 | thyA | LSL_0707 | LSL_0708 | ABC transporter, ATP-binding protein; COG0488 [R] ATPase components of ABC transporters with duplicated ATPase domains. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.753 |
| dapB | LSL_0707 | LSL_0705 | LSL_0707 | Dihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate. | ABC transporter, ATP-binding protein; COG0488 [R] ATPase components of ABC transporters with duplicated ATPase domains. | 0.787 |
| dapB | folA | LSL_0705 | LSL_0709 | Dihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate. | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | 0.710 |
| dapB | pcnB | LSL_0705 | LSL_0706 | Dihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate. | Poly(A) polymerase / tRNA nucleotidyltransferase; Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate. | 0.951 |
| dapB | thyA | LSL_0705 | LSL_0708 | Dihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.787 |
| folA | LSL_0707 | LSL_0709 | LSL_0707 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | ABC transporter, ATP-binding protein; COG0488 [R] ATPase components of ABC transporters with duplicated ATPase domains. | 0.735 |
| folA | dapB | LSL_0709 | LSL_0705 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Dihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate. | 0.710 |
| folA | pcnB | LSL_0709 | LSL_0706 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Poly(A) polymerase / tRNA nucleotidyltransferase; Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate. | 0.816 |
| folA | thyA | LSL_0709 | LSL_0708 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.999 |
| pcnB | LSL_0707 | LSL_0706 | LSL_0707 | Poly(A) polymerase / tRNA nucleotidyltransferase; Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate. | ABC transporter, ATP-binding protein; COG0488 [R] ATPase components of ABC transporters with duplicated ATPase domains. | 0.797 |
| pcnB | dapB | LSL_0706 | LSL_0705 | Poly(A) polymerase / tRNA nucleotidyltransferase; Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate. | Dihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate. | 0.951 |
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