STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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Score
dltCD-alanine-poly(phosphoribitol)ligase subunit 2; Carrier protein involved in the D-alanylation of lipoteichoic acid (LTA). The loading of thioester-linked D-alanine onto DltC is catalyzed by D-alanine--D-alanyl carrier protein ligase DltA. The DltC- carried D-alanyl group is further transferred to cell membrane phosphatidylglycerol (PG) by forming an ester bond, probably catalyzed by DltD. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall. (75 aa)    
Predicted Functional Partners:
dltD
Protein dltD precursor; COG3966 [M] Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein).
 
 
 0.999
dltB
Protein dltB; Could be involved in the transport of activated D-alanine through the membrane.
 
 0.999
dltA
D-alanine-activating enzyme; Catalyzes the first step in the D-alanylation of lipoteichoic acid (LTA), the activation of D-alanine and its transfer onto the D- alanyl carrier protein (Dcp) DltC. In an ATP-dependent two-step reaction, forms a high energy D-alanyl-AMP intermediate, followed by transfer of the D-alanyl residue as a thiol ester to the phosphopantheinyl prosthetic group of the Dcp. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall. Belongs to the ATP-dependent AMP [...]
 
 
 0.999
alr
Alanine racemase; Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids; Belongs to the alanine racemase family.
    
  0.904
LSL_1670
D-alanine aminotransferase; COG0115 [EH] Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase.
  
 
 0.904
ddlA
D-alanine--D-alanine ligase; Cell wall formation.
     
 0.901
LSL_0180
Transcriptional regulator, LytR family; COG0583 [K] Transcriptional regulator.
     
  0.900
LSL_1477
Transcriptional regulator, LytR family; COG0583 [K] Transcriptional regulator.
     
  0.900
LSL_1551
Transcriptional regulator, LytR family; COG0583 [K] Transcriptional regulator.
     
  0.900
fabD
Malonyl-CoA-[acyl-carrier-protein] transacylase; COG0331 [I] (acyl-carrier-protein) S-malonyltransferase.
  
 0.796
Your Current Organism:
Lactobacillus salivarius
NCBI taxonomy Id: 362948
Other names: L. salivarius UCC118, Lactobacillus salivarius UCC118, Lactobacillus salivarius str. UCC118, Lactobacillus salivarius strain UCC118, Lactobacillus salivarius subsp. salivarius UCC118
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