Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
LSL_1002Hydrolase, HAD superfamily; COG0561 [R] Predicted hydrolases of the HAD superfamily. (269 aa)    
Predicted Functional Partners:
LSL_1001
Conserved hypothetical protein; COG1073 [R] Hydrolases of the alpha/beta superfamily.
       0.619
LSL_0999
Putative 23S rRNA m(5)C methyltransferase; COG0144 [J] tRNA and rRNA cytosine-C5-methylases.
       0.594
LSL_1000
Hypothetical membrane spanning protein.
       0.525
wecD-4
Acetyltransferase, GNAT family; COG0454 [KR] Histone acetyltransferase HPA2 and related acetyltransferases.
  
    0.500
acoA
Pyruvate dehydrogenase E1 component alpha subunit; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3).
   
    0.487
acoB
COG0022 [C] Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit.
   
    0.481
aceF
COG0508 [C] Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component, and related enzymes.
   
    0.480
ribF
Riboflavin kinase / FMN adenylyltransferase; COG0196 [H] FAD synthase; Belongs to the ribF family.
   
 
 0.427
Your Current Organism:
Lactobacillus salivarius
NCBI taxonomy Id: 362948
Other names: L. salivarius UCC118, Lactobacillus salivarius UCC118, Lactobacillus salivarius str. UCC118, Lactobacillus salivarius strain UCC118, Lactobacillus salivarius subsp. salivarius UCC118
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