Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
minCCell division inhibitor; Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization. (223 aa)    
Predicted Functional Partners:
minD
Cell division inhibitor; COG2894 [D] Septum formation inhibitor-activating ATPase.
 
 
 0.999
mreD
COG1792 [M] Cell shape-determining protein.
 
  
 0.994
mreC
Rod shape-determining protein; Involved in formation and maintenance of cell shape.
  
  
 0.983
ftsZ
Cell division protein; Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.
   
 
 0.892
divIVA-2
COG3599 [D] Cell division initiation protein.
 
  
 0.833
mreB-2
Rod shape-determining protein; COG1077 [D] Actin-like ATPase involved in cell morphogenesis.
  
  
 0.808
LSL_1183
Hypothetical membrane spanning protein; COG0265 [O] Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain.
  
   
 0.790
sepF
Conserved hypothetical protein; Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA.
  
  
 0.699
LSL_1244
Conserved hypothetical protein; COG3688 [R] Predicted RNA-binding protein containing a PIN domain.
  
     0.651
LSL_1222
Initiation-control protein; Involved in initiation control of chromosome replication. Belongs to the YabA family.
  
     0.635
Your Current Organism:
Lactobacillus salivarius
NCBI taxonomy Id: 362948
Other names: L. salivarius UCC118, Lactobacillus salivarius UCC118, Lactobacillus salivarius str. UCC118, Lactobacillus salivarius strain UCC118, Lactobacillus salivarius subsp. salivarius UCC118
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