Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
luxSAutoinducer-2 production protein / Ribosylhomocysteinase; Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD). Belongs to the LuxS family. (156 aa)    
Predicted Functional Partners:
pfs
5'-methylthioadenosine nucleosidase / S-adenosylhomocysteine nucleosidase; Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'- methylthioribose and S-ribosylhomocysteine, respectively. Belongs to the PNP/UDP phosphorylase family. MtnN subfamily.
 
 
 0.991
metC
COG0626 [E] Cystathionine beta-lyases/cystathionine gamma-synthases.
  
 
 0.954
MmuM
COG2040 [E] Homocysteine/selenocysteine methylase (S-methylmethionine-dependent).
     
 0.907
LSL_0204
Aminotransferase class I and II; COG1168 [E] Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities.
     
 0.900
LSL_1499
Aminotransferase; COG1168 [E] Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities.
     
 0.900
cysK
COG0031 [E] Cysteine synthase.
  
 
 0.879
cysK-2
COG0031 [E] Cysteine synthase; Belongs to the cysteine synthase/cystathionine beta- synthase family.
  
 
 0.879
thrA
COG0460 [E] Homoserine dehydrogenase.
     
 0.814
thrB
Homoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily.
     
  0.800
metE
5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase; COG0620 [E] Methionine synthase II (cobalamin-independent).
 
  
 0.712
Your Current Organism:
Lactobacillus salivarius
NCBI taxonomy Id: 362948
Other names: L. salivarius UCC118, Lactobacillus salivarius UCC118, Lactobacillus salivarius str. UCC118, Lactobacillus salivarius strain UCC118, Lactobacillus salivarius subsp. salivarius UCC118
Server load: low (28%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.