Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
LSL_1180COG0583 [K] Transcriptional regulator. (112 aa)    
Predicted Functional Partners:
LSL_1179
COG0344 [S] Predicted membrane protein.
  
    0.948
LSL_1183
Hypothetical membrane spanning protein; COG0265 [O] Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain.
  
  
 0.828
LSL_1182
Alkaline phosphatase synthesis two-component response regulator phoP; COG0745 [TK] Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain.
  
    0.788
baeS-4
Two component system histidine kinase; COG0642 [T] Signal transduction histidine kinase.
       0.758
hprK
HPR(SER) kinase / phosphatase; Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr). The two antagonistic activities of HprK/P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable c [...]
       0.729
lgt
Prolipoprotein diacylglyceryl transferase; Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins; Belongs to the Lgt family.
       0.707
degP
Endopeptidase; COG0265 [O] Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain.
   
  
 0.515
baeS-3
Two component system histidine kinase; COG0642 [T] Signal transduction histidine kinase.
  
 
 0.512
LSL_0108
COG0583 [K] Transcriptional regulator.
  
     0.480
LSL_1184
Transposase ISLasa4m, ISL3 family; COG0675 [L] Transposase and inactivated derivatives.
       0.455
Your Current Organism:
Lactobacillus salivarius
NCBI taxonomy Id: 362948
Other names: L. salivarius UCC118, Lactobacillus salivarius UCC118, Lactobacillus salivarius str. UCC118, Lactobacillus salivarius strain UCC118, Lactobacillus salivarius subsp. salivarius UCC118
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