node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
LSL_0399 | LSL_1305 | LSL_0399 | LSL_1305 | Conserved hypothetical protein; COG2761 [Q] Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis. | GTP pyrophosphokinase; COG0718 [S] Uncharacterized protein conserved in bacteria. | 0.493 |
LSL_0399 | nadK | LSL_0399 | LSL_1304 | Conserved hypothetical protein; COG2761 [Q] Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis. | ATP-NAD kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. | 0.493 |
LSL_0399 | rluD-2 | LSL_0399 | LSL_1303 | Conserved hypothetical protein; COG2761 [Q] Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis. | Ribosomal large subunit pseudouridine synthase D; Responsible for synthesis of pseudouridine from uracil. Belongs to the pseudouridine synthase RluA family. | 0.482 |
LSL_0537 | nadK | LSL_0537 | LSL_1304 | Hemolysin; COG1189 [J] Predicted rRNA methylase. | ATP-NAD kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. | 0.500 |
LSL_0615 | nadK | LSL_0615 | LSL_1304 | 16S rRNA m(5)C 967 methyltransferase; Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA. | ATP-NAD kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. | 0.502 |
LSL_0615 | polA | LSL_0615 | LSL_0488 | 16S rRNA m(5)C 967 methyltransferase; Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA. | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity. | 0.687 |
LSL_1305 | LSL_0399 | LSL_1305 | LSL_0399 | GTP pyrophosphokinase; COG0718 [S] Uncharacterized protein conserved in bacteria. | Conserved hypothetical protein; COG2761 [Q] Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis. | 0.493 |
LSL_1305 | mgtE | LSL_1305 | LSL_1302 | GTP pyrophosphokinase; COG0718 [S] Uncharacterized protein conserved in bacteria. | Mg2+ transporter; Acts as a magnesium transporter. | 0.806 |
LSL_1305 | nadK | LSL_1305 | LSL_1304 | GTP pyrophosphokinase; COG0718 [S] Uncharacterized protein conserved in bacteria. | ATP-NAD kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. | 0.875 |
LSL_1305 | rluD-2 | LSL_1305 | LSL_1303 | GTP pyrophosphokinase; COG0718 [S] Uncharacterized protein conserved in bacteria. | Ribosomal large subunit pseudouridine synthase D; Responsible for synthesis of pseudouridine from uracil. Belongs to the pseudouridine synthase RluA family. | 0.837 |
mgtE | LSL_1305 | LSL_1302 | LSL_1305 | Mg2+ transporter; Acts as a magnesium transporter. | GTP pyrophosphokinase; COG0718 [S] Uncharacterized protein conserved in bacteria. | 0.806 |
mgtE | nadK | LSL_1302 | LSL_1304 | Mg2+ transporter; Acts as a magnesium transporter. | ATP-NAD kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. | 0.844 |
mgtE | rluD-2 | LSL_1302 | LSL_1303 | Mg2+ transporter; Acts as a magnesium transporter. | Ribosomal large subunit pseudouridine synthase D; Responsible for synthesis of pseudouridine from uracil. Belongs to the pseudouridine synthase RluA family. | 0.835 |
nadD | nadE | LSL_0502 | LSL_1260 | Nicotinate-nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). | NH(3)-dependent NAD(+) synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source. | 0.950 |
nadD | nadK | LSL_0502 | LSL_1304 | Nicotinate-nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). | ATP-NAD kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. | 0.935 |
nadD | polA | LSL_0502 | LSL_0488 | Nicotinate-nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity. | 0.530 |
nadD | sir2 | LSL_0502 | LSL_0203 | Nicotinate-nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). | SIR2 family protein; NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form; Belongs to the sirtuin family. Class U subfamily. | 0.934 |
nadE | nadD | LSL_1260 | LSL_0502 | NH(3)-dependent NAD(+) synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source. | Nicotinate-nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). | 0.950 |
nadE | nadK | LSL_1260 | LSL_1304 | NH(3)-dependent NAD(+) synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source. | ATP-NAD kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. | 0.933 |
nadE | sir2 | LSL_1260 | LSL_0203 | NH(3)-dependent NAD(+) synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source. | SIR2 family protein; NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form; Belongs to the sirtuin family. Class U subfamily. | 0.923 |