nadK protein (Lactobacillus salivarius) - STRING interaction network

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nadK

ATP-NAD kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. (268 aa)

Predicted Functional Partners:

nadD

0.944

nadE

0.943

sir2

0.916

rluD-2

0.865

LSL_1305

0.863

mgtE

0.831

polA

0.591

LSL_0537

0.582

pta

0.540

topB

0.495

Your Current Organism:

Lactobacillus salivarius

NCBI taxonomy Id: 362948
Other names: L. salivarius UCC118, Lactobacillus salivarius UCC118, Lactobacillus salivarius str. UCC118, Lactobacillus salivarius strain UCC118, Lactobacillus salivarius subsp. salivarius UCC118

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LSL_0537	nadK	LSL_0537	LSL_1304	Hemolysin; COG1189 [J] Predicted rRNA methylase.	ATP-NAD kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.	0.582
LSL_1305	mgtE	LSL_1305	LSL_1302	GTP pyrophosphokinase; COG0718 [S] Uncharacterized protein conserved in bacteria.	Mg2+ transporter; Acts as a magnesium transporter.	0.787
LSL_1305	nadK	LSL_1305	LSL_1304	GTP pyrophosphokinase; COG0718 [S] Uncharacterized protein conserved in bacteria.	ATP-NAD kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.	0.863
LSL_1305	rluD-2	LSL_1305	LSL_1303	GTP pyrophosphokinase; COG0718 [S] Uncharacterized protein conserved in bacteria.	Ribosomal large subunit pseudouridine synthase D; Responsible for synthesis of pseudouridine from uracil. Belongs to the pseudouridine synthase RluA family.	0.823
LSL_1305	topB	LSL_1305	LSL_1306	GTP pyrophosphokinase; COG0718 [S] Uncharacterized protein conserved in bacteria.	DNA topoisomerase III; COG0550 [L] Topoisomerase IA.	0.552
mgtE	LSL_1305	LSL_1302	LSL_1305	Mg2+ transporter; Acts as a magnesium transporter.	GTP pyrophosphokinase; COG0718 [S] Uncharacterized protein conserved in bacteria.	0.787
mgtE	nadK	LSL_1302	LSL_1304	Mg2+ transporter; Acts as a magnesium transporter.	ATP-NAD kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.	0.831
mgtE	rluD-2	LSL_1302	LSL_1303	Mg2+ transporter; Acts as a magnesium transporter.	Ribosomal large subunit pseudouridine synthase D; Responsible for synthesis of pseudouridine from uracil. Belongs to the pseudouridine synthase RluA family.	0.802
mgtE	topB	LSL_1302	LSL_1306	Mg2+ transporter; Acts as a magnesium transporter.	DNA topoisomerase III; COG0550 [L] Topoisomerase IA.	0.510
nadD	nadE	LSL_0502	LSL_1260	Nicotinate-nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).	NH(3)-dependent NAD(+) synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source.	0.973
nadD	nadK	LSL_0502	LSL_1304	Nicotinate-nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).	ATP-NAD kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.	0.944
nadD	polA	LSL_0502	LSL_0488	Nicotinate-nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).	DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity.	0.462
nadD	sir2	LSL_0502	LSL_0203	Nicotinate-nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).	SIR2 family protein; NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form; Belongs to the sirtuin family. Class U subfamily.	0.923
nadE	nadD	LSL_1260	LSL_0502	NH(3)-dependent NAD(+) synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source.	Nicotinate-nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).	0.973
nadE	nadK	LSL_1260	LSL_1304	NH(3)-dependent NAD(+) synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source.	ATP-NAD kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.	0.943
nadE	sir2	LSL_1260	LSL_0203	NH(3)-dependent NAD(+) synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source.	SIR2 family protein; NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form; Belongs to the sirtuin family. Class U subfamily.	0.921
nadK	LSL_0537	LSL_1304	LSL_0537	ATP-NAD kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.	Hemolysin; COG1189 [J] Predicted rRNA methylase.	0.582
nadK	LSL_1305	LSL_1304	LSL_1305	ATP-NAD kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.	GTP pyrophosphokinase; COG0718 [S] Uncharacterized protein conserved in bacteria.	0.863
nadK	mgtE	LSL_1304	LSL_1302	ATP-NAD kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.	Mg2+ transporter; Acts as a magnesium transporter.	0.831
nadK	nadD	LSL_1304	LSL_0502	ATP-NAD kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.	Nicotinate-nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).	0.944

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