Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
trxA-3Thioredoxin; COG0526 [OC] Thiol-disulfide isomerase and thioredoxins; Belongs to the thioredoxin family. (107 aa)    
Predicted Functional Partners:
trxB-2
COG0492 [O] Thioredoxin reductase.
  
 
 0.772
arsC-2
Arsenate reductase; COG0394 [T] Protein-tyrosine-phosphatase; Belongs to the low molecular weight phosphotyrosine protein phosphatase family.
  
 
 0.730
nrdA
Ribonucleoside-diphosphate reductase alpha chain; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.
  
 
 0.728
trxB
COG0492 [O] Thioredoxin reductase.
  
 
 0.710
groL
60 kDa chaperonin GROEL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions.
  
 
 0.708
crcB
CrcB family protein; Important for reducing fluoride concentration in the cell, thus reducing its toxicity; Belongs to the CrcB (TC 9.B.71) family.
       0.603
crcB-2
CrcB family protein; Important for reducing fluoride concentration in the cell, thus reducing its toxicity; Belongs to the CrcB (TC 9.B.71) family.
       0.603
LSL_1476
Hydrolase, HAD superfamily; COG0561 [R] Predicted hydrolases of the HAD superfamily.
  
    0.573
LSL_1686
Thioredoxin peroxidase; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.
  
 
 0.567
nrdB
COG0208 [F] Ribonucleotide reductase, beta subunit.
  
 
 0.550
Your Current Organism:
Lactobacillus salivarius
NCBI taxonomy Id: 362948
Other names: L. salivarius UCC118, Lactobacillus salivarius UCC118, Lactobacillus salivarius str. UCC118, Lactobacillus salivarius strain UCC118, Lactobacillus salivarius subsp. salivarius UCC118
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