Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
glpF-3COG0580 [G] Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family); Belongs to the MIP/aquaporin (TC 1.A.8) family. (235 aa)    
Predicted Functional Partners:
dAK
COG2376 [G] Dihydroxyacetone kinase.
  
  
 0.823
LSL_1631
COG0718 [S] Uncharacterized protein conserved in bacteria.
  
    0.813
dAK-2
COG2376 [G] Dihydroxyacetone kinase.
  
  
 0.753
glpK
Glycerol kinase; Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate; Belongs to the FGGY kinase family.
 
 
 0.751
glpO
Alpha-glycerophosphate oxidase; COG0240 [C] Glycerol-3-phosphate dehydrogenase.
  
  
 0.648
fruA
COG1299 [G] Phosphotransferase system, fructose-specific IIC component.
   
  
 0.621
dAK-3
COG2376 [G] Dihydroxyacetone kinase.
  
  
 0.560
dnaJ
Chaperone protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK a [...]
    
 
 0.544
LSL_0471
Transcription regulator, Crp family; COG0583 [K] Transcriptional regulator.
   
 0.482
LSL_0616
Protein phosphatase 2C; COG0631 [T] Serine/threonine protein phosphatase.
    
   0.482
Your Current Organism:
Lactobacillus salivarius
NCBI taxonomy Id: 362948
Other names: L. salivarius UCC118, Lactobacillus salivarius UCC118, Lactobacillus salivarius str. UCC118, Lactobacillus salivarius strain UCC118, Lactobacillus salivarius subsp. salivarius UCC118
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