| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| LSL_0447 | LSL_1670 | LSL_0447 | LSL_1670 | Xaa-His dipeptidase; COG0624 [E] Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases. | D-alanine aminotransferase; COG0115 [EH] Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase. | 0.471 |
| LSL_0447 | pepO | LSL_0447 | LSL_1669 | Xaa-His dipeptidase; COG0624 [E] Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases. | COG3590 [O] Predicted metalloendopeptidase. | 0.622 |
| LSL_1670 | LSL_0447 | LSL_1670 | LSL_0447 | D-alanine aminotransferase; COG0115 [EH] Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase. | Xaa-His dipeptidase; COG0624 [E] Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases. | 0.471 |
| LSL_1670 | alr | LSL_1670 | LSL_0358 | D-alanine aminotransferase; COG0115 [EH] Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase. | Alanine racemase; Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids; Belongs to the alanine racemase family. | 0.939 |
| LSL_1670 | birA | LSL_1670 | LSL_0325 | D-alanine aminotransferase; COG0115 [EH] Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase. | Biotin operon repressor / Biotin--[acetyl-CoA-carboxylase] synthetase; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a repressor; Belongs to the biotin--protein ligase family. | 0.437 |
| LSL_1670 | ddlA | LSL_1670 | LSL_1083 | D-alanine aminotransferase; COG0115 [EH] Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase. | D-alanine--D-alanine ligase; Cell wall formation. | 0.912 |
| LSL_1670 | dltA | LSL_1670 | LSL_0892 | D-alanine aminotransferase; COG0115 [EH] Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase. | D-alanine-activating enzyme; Catalyzes the first step in the D-alanylation of lipoteichoic acid (LTA), the activation of D-alanine and its transfer onto the D- alanyl carrier protein (Dcp) DltC. In an ATP-dependent two-step reaction, forms a high energy D-alanyl-AMP intermediate, followed by transfer of the D-alanyl residue as a thiol ester to the phosphopantheinyl prosthetic group of the Dcp. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall. Belongs to the ATP-dependent AMP [...] | 0.911 |
| LSL_1670 | dltC | LSL_1670 | LSL_0890 | D-alanine aminotransferase; COG0115 [EH] Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase. | D-alanine-poly(phosphoribitol)ligase subunit 2; Carrier protein involved in the D-alanylation of lipoteichoic acid (LTA). The loading of thioester-linked D-alanine onto DltC is catalyzed by D-alanine--D-alanyl carrier protein ligase DltA. The DltC- carried D-alanyl group is further transferred to cell membrane phosphatidylglycerol (PG) by forming an ester bond, probably catalyzed by DltD. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall. | 0.904 |
| LSL_1670 | lysC | LSL_1670 | LSL_1058 | D-alanine aminotransferase; COG0115 [EH] Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase. | COG0527 [E] Aspartokinases; Belongs to the aspartokinase family. | 0.452 |
| LSL_1670 | mbp2 | LSL_1670 | LSL_0311 | D-alanine aminotransferase; COG0115 [EH] Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase. | Mucus binding protein; COG3652 [S] Predicted outer membrane protein. | 0.534 |
| LSL_1670 | pepO | LSL_1670 | LSL_1669 | D-alanine aminotransferase; COG0115 [EH] Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase. | COG3590 [O] Predicted metalloendopeptidase. | 0.496 |
| LSL_1670 | pykF | LSL_1670 | LSL_0867 | D-alanine aminotransferase; COG0115 [EH] Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase. | COG0469 [G] Pyruvate kinase; Belongs to the pyruvate kinase family. | 0.447 |
| alr | LSL_1670 | LSL_0358 | LSL_1670 | Alanine racemase; Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids; Belongs to the alanine racemase family. | D-alanine aminotransferase; COG0115 [EH] Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase. | 0.939 |
| alr | birA | LSL_0358 | LSL_0325 | Alanine racemase; Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids; Belongs to the alanine racemase family. | Biotin operon repressor / Biotin--[acetyl-CoA-carboxylase] synthetase; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a repressor; Belongs to the biotin--protein ligase family. | 0.652 |
| alr | ddlA | LSL_0358 | LSL_1083 | Alanine racemase; Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids; Belongs to the alanine racemase family. | D-alanine--D-alanine ligase; Cell wall formation. | 0.974 |
| alr | dltA | LSL_0358 | LSL_0892 | Alanine racemase; Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids; Belongs to the alanine racemase family. | D-alanine-activating enzyme; Catalyzes the first step in the D-alanylation of lipoteichoic acid (LTA), the activation of D-alanine and its transfer onto the D- alanyl carrier protein (Dcp) DltC. In an ATP-dependent two-step reaction, forms a high energy D-alanyl-AMP intermediate, followed by transfer of the D-alanyl residue as a thiol ester to the phosphopantheinyl prosthetic group of the Dcp. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall. Belongs to the ATP-dependent AMP [...] | 0.936 |
| alr | dltC | LSL_0358 | LSL_0890 | Alanine racemase; Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids; Belongs to the alanine racemase family. | D-alanine-poly(phosphoribitol)ligase subunit 2; Carrier protein involved in the D-alanylation of lipoteichoic acid (LTA). The loading of thioester-linked D-alanine onto DltC is catalyzed by D-alanine--D-alanyl carrier protein ligase DltA. The DltC- carried D-alanyl group is further transferred to cell membrane phosphatidylglycerol (PG) by forming an ester bond, probably catalyzed by DltD. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall. | 0.904 |
| alr | lysC | LSL_0358 | LSL_1058 | Alanine racemase; Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids; Belongs to the alanine racemase family. | COG0527 [E] Aspartokinases; Belongs to the aspartokinase family. | 0.428 |
| birA | LSL_1670 | LSL_0325 | LSL_1670 | Biotin operon repressor / Biotin--[acetyl-CoA-carboxylase] synthetase; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a repressor; Belongs to the biotin--protein ligase family. | D-alanine aminotransferase; COG0115 [EH] Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase. | 0.437 |
| birA | alr | LSL_0325 | LSL_0358 | Biotin operon repressor / Biotin--[acetyl-CoA-carboxylase] synthetase; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a repressor; Belongs to the biotin--protein ligase family. | Alanine racemase; Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids; Belongs to the alanine racemase family. | 0.652 |