node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
cysG | hemA | LI0117 | LI0322 | Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain). | Glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). | 0.833 |
cysG | hemB | LI0117 | LI0205 | Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain). | Delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. | 0.995 |
cysG | hemC | LI0117 | LI1011 | Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain). | Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. | 0.999 |
cysG | hemL | LI0117 | LI0906 | Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain). | Glutamate-1-semialdehyde aminotransferase. | 0.604 |
cysG | ribD | LI0117 | LI0157 | Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain). | Pyrimidine reductase, riboflavin biosynthesis; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | 0.624 |
cysG | ribH | LI0117 | LI0154 | Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain). | Riboflavin synthase beta-chain; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin. | 0.450 |
fabF/fabB | hemL | LI0160 | LI0906 | 3-oxoacyl-(acyl-carrier-protein) synthase; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. | Glutamate-1-semialdehyde aminotransferase. | 0.718 |
guaA | hemB | LI0590 | LI0205 | GMP synthase-Glutamine amidotransferase domain; Catalyzes the synthesis of GMP from XMP. | Delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. | 0.420 |
guaA | hemL | LI0590 | LI0906 | GMP synthase-Glutamine amidotransferase domain; Catalyzes the synthesis of GMP from XMP. | Glutamate-1-semialdehyde aminotransferase. | 0.568 |
guaA | ribD | LI0590 | LI0157 | GMP synthase-Glutamine amidotransferase domain; Catalyzes the synthesis of GMP from XMP. | Pyrimidine reductase, riboflavin biosynthesis; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | 0.711 |
hemA | cysG | LI0322 | LI0117 | Glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). | Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain). | 0.833 |
hemA | hemB | LI0322 | LI0205 | Glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). | Delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. | 0.781 |
hemA | hemC | LI0322 | LI1011 | Glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). | Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. | 0.991 |
hemA | hemL | LI0322 | LI0906 | Glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). | Glutamate-1-semialdehyde aminotransferase. | 0.989 |
hemA | ribD | LI0322 | LI0157 | Glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). | Pyrimidine reductase, riboflavin biosynthesis; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | 0.428 |
hemA | thiE | LI0322 | LI0324 | Glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). | Thiamine monophosphate synthase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family. | 0.451 |
hemB | cysG | LI0205 | LI0117 | Delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. | Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain). | 0.995 |
hemB | guaA | LI0205 | LI0590 | Delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. | GMP synthase-Glutamine amidotransferase domain; Catalyzes the synthesis of GMP from XMP. | 0.420 |
hemB | hemA | LI0205 | LI0322 | Delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. | Glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). | 0.781 |
hemB | hemC | LI0205 | LI1011 | Delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. | Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. | 0.996 |