STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PF3D7_1368800DNA repair endonuclease XPF, putative. (1700 aa)    
Predicted Functional Partners:
PF3D7_0203300
ERCC1 nucleotide excision repair protein, putative.
   
 0.999
PF3D7_0710400
DNA repair protein RAD14, putative.
    
 0.975
PF3D7_1347100
DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family.
    
 
 0.959
PF3D7_1447800
Calponin homology domain-containing protein, putative.
   
 
 0.930
PF3D7_1449400
Crossover junction endonuclease MUS81, putative.
    
 
 0.918
PF3D7_0105900
3'-5' exonuclease, putative.
   
 
 0.915
PF3D7_1107400
DNA repair protein RAD51 homolog; Binds to single and double-stranded DNA and exhibits DNA- dependent ATPase activity. Underwinds duplex DNA. Belongs to the RecA family. RAD51 subfamily.
   
 
 0.882
PF3D7_0904800
Replication protein A1, small.
    
 
 0.881
PF3D7_0409600
Replication protein A1, large subunit.
    
 
 0.881
PF3D7_0507700
Nuclear protein localization protein 4, putative.
   
 
 0.850
Your Current Organism:
Plasmodium falciparum
NCBI taxonomy Id: 36329
Other names: P. falciparum 3D7, Plasmodium falciparum (isolate 3D7), Plasmodium falciparum 3D7
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.