node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
SET32197.1 | SET68941.1 | SAMN04489858_104162 | SAMN04489858_10881 | Acetolactate synthase-1/2/3 large subunit; Belongs to the TPP enzyme family. | Acetolactate synthase, small subunit. | 0.992 |
SET32197.1 | SET68965.1 | SAMN04489858_104162 | SAMN04489858_10882 | Acetolactate synthase-1/2/3 large subunit; Belongs to the TPP enzyme family. | Acetolactate synthase, large subunit. | 0.821 |
SET32197.1 | ilvA | SAMN04489858_104162 | SAMN04489858_105211 | Acetolactate synthase-1/2/3 large subunit; Belongs to the TPP enzyme family. | L-threonine ammonia-lyase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | 0.911 |
SET32197.1 | ilvC | SAMN04489858_104162 | SAMN04489858_102118 | Acetolactate synthase-1/2/3 large subunit; Belongs to the TPP enzyme family. | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.975 |
SET32197.1 | leuA | SAMN04489858_104162 | SAMN04489858_101166 | Acetolactate synthase-1/2/3 large subunit; Belongs to the TPP enzyme family. | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. | 0.888 |
SET32197.1 | leuB | SAMN04489858_104162 | SAMN04489858_101466 | Acetolactate synthase-1/2/3 large subunit; Belongs to the TPP enzyme family. | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. | 0.939 |
SET36802.1 | SET68941.1 | SAMN04489858_104336 | SAMN04489858_10881 | Sulfoacetaldehyde acetyltransferase. | Acetolactate synthase, small subunit. | 0.976 |
SET36802.1 | ilvA | SAMN04489858_104336 | SAMN04489858_105211 | Sulfoacetaldehyde acetyltransferase. | L-threonine ammonia-lyase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | 0.502 |
SET36802.1 | ilvC | SAMN04489858_104336 | SAMN04489858_102118 | Sulfoacetaldehyde acetyltransferase. | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.777 |
SET36802.1 | leuA | SAMN04489858_104336 | SAMN04489858_101166 | Sulfoacetaldehyde acetyltransferase. | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. | 0.565 |
SET36802.1 | leuB | SAMN04489858_104336 | SAMN04489858_101466 | Sulfoacetaldehyde acetyltransferase. | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. | 0.505 |
SET68941.1 | SET32197.1 | SAMN04489858_10881 | SAMN04489858_104162 | Acetolactate synthase, small subunit. | Acetolactate synthase-1/2/3 large subunit; Belongs to the TPP enzyme family. | 0.992 |
SET68941.1 | SET36802.1 | SAMN04489858_10881 | SAMN04489858_104336 | Acetolactate synthase, small subunit. | Sulfoacetaldehyde acetyltransferase. | 0.976 |
SET68941.1 | SET68965.1 | SAMN04489858_10881 | SAMN04489858_10882 | Acetolactate synthase, small subunit. | Acetolactate synthase, large subunit. | 0.999 |
SET68941.1 | SET80738.1 | SAMN04489858_10881 | SAMN04489858_110100 | Acetolactate synthase, small subunit. | Sulfoacetaldehyde acetyltransferase; Belongs to the TPP enzyme family. | 0.976 |
SET68941.1 | SET83247.1 | SAMN04489858_10881 | SAMN04489858_11179 | Acetolactate synthase, small subunit. | Acetolactate synthase-1/2/3 large subunit; Belongs to the TPP enzyme family. | 0.983 |
SET68941.1 | SEU06673.1 | SAMN04489858_10881 | SAMN04489858_12315 | Acetolactate synthase, small subunit. | Acetolactate synthase-1/2/3 large subunit; Belongs to the TPP enzyme family. | 0.987 |
SET68941.1 | ilvA | SAMN04489858_10881 | SAMN04489858_105211 | Acetolactate synthase, small subunit. | L-threonine ammonia-lyase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | 0.979 |
SET68941.1 | ilvC | SAMN04489858_10881 | SAMN04489858_102118 | Acetolactate synthase, small subunit. | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.999 |
SET68941.1 | leuA | SAMN04489858_10881 | SAMN04489858_101166 | Acetolactate synthase, small subunit. | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. | 0.979 |