SEW39777.1 protein (Cognatiyoonia koreensis)

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second shell of interactors

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a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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protein homology

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Score

SEW39777.1

Putative signal transducing protein. (83 aa)

Predicted Functional Partners:

SEW39787.1

0.856

SEW39769.1

0.739

SEW39795.1

0.705

rsmI

0.573

SEW38803.1

0.560

SEW30847.1

0.545

SEW41217.1

0.512

SEV99301.1

0.503

SEW26907.1

0.468

SEW22837.1

0.456

Your Current Organism:

Cognatiyoonia koreensis

NCBI taxonomy Id: 364200
Other names: C. koreensis, CIP 109899,, DSM 17925, KACC 11519, Loktanella koreensis, Loktanella koreensis Weon et al. 2006, strain GA2-M3

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
SEV99301.1	SEW30847.1	SAMN04488515_0555	SAMN04488515_2184	Tetratricopeptide repeat-containing protein.	N-terminal double-transmembrane domain-containing protein.	0.657
SEV99301.1	SEW38803.1	SAMN04488515_0555	SAMN04488515_2514	Tetratricopeptide repeat-containing protein.	TIGR02302 family protein.	0.656
SEV99301.1	SEW39777.1	SAMN04488515_0555	SAMN04488515_2630	Tetratricopeptide repeat-containing protein.	Putative signal transducing protein.	0.503
SEW22837.1	SEW39777.1	SAMN04488515_1721	SAMN04488515_2630	Poly(3-hydroxybutyrate) depolymerase.	Putative signal transducing protein.	0.456
SEW26907.1	SEW30847.1	SAMN04488515_1946	SAMN04488515_2184	Hypothetical protein.	N-terminal double-transmembrane domain-containing protein.	0.692
SEW26907.1	SEW39777.1	SAMN04488515_1946	SAMN04488515_2630	Hypothetical protein.	Putative signal transducing protein.	0.468
SEW30847.1	SEV99301.1	SAMN04488515_2184	SAMN04488515_0555	N-terminal double-transmembrane domain-containing protein.	Tetratricopeptide repeat-containing protein.	0.657
SEW30847.1	SEW26907.1	SAMN04488515_2184	SAMN04488515_1946	N-terminal double-transmembrane domain-containing protein.	Hypothetical protein.	0.692
SEW30847.1	SEW38803.1	SAMN04488515_2184	SAMN04488515_2514	N-terminal double-transmembrane domain-containing protein.	TIGR02302 family protein.	0.774
SEW30847.1	SEW39777.1	SAMN04488515_2184	SAMN04488515_2630	N-terminal double-transmembrane domain-containing protein.	Putative signal transducing protein.	0.545
SEW38803.1	SEV99301.1	SAMN04488515_2514	SAMN04488515_0555	TIGR02302 family protein.	Tetratricopeptide repeat-containing protein.	0.656
SEW38803.1	SEW30847.1	SAMN04488515_2514	SAMN04488515_2184	TIGR02302 family protein.	N-terminal double-transmembrane domain-containing protein.	0.774
SEW38803.1	SEW39777.1	SAMN04488515_2514	SAMN04488515_2630	TIGR02302 family protein.	Putative signal transducing protein.	0.560
SEW38803.1	SEW41217.1	SAMN04488515_2514	SAMN04488515_2799	TIGR02302 family protein.	Protein of unknown function.	0.757
SEW39769.1	SEW39777.1	SAMN04488515_2629	SAMN04488515_2630	Octaprenyl-diphosphate synthase; Belongs to the FPP/GGPP synthase family.	Putative signal transducing protein.	0.739
SEW39769.1	SEW39787.1	SAMN04488515_2629	SAMN04488515_2631	Octaprenyl-diphosphate synthase; Belongs to the FPP/GGPP synthase family.	tRNA1(Val) A37 N6-methylase TrmN6; Belongs to the methyltransferase superfamily.	0.739
SEW39769.1	SEW39795.1	SAMN04488515_2629	SAMN04488515_2632	Octaprenyl-diphosphate synthase; Belongs to the FPP/GGPP synthase family.	Hypothetical protein.	0.622
SEW39777.1	SEV99301.1	SAMN04488515_2630	SAMN04488515_0555	Putative signal transducing protein.	Tetratricopeptide repeat-containing protein.	0.503
SEW39777.1	SEW22837.1	SAMN04488515_2630	SAMN04488515_1721	Putative signal transducing protein.	Poly(3-hydroxybutyrate) depolymerase.	0.456
SEW39777.1	SEW26907.1	SAMN04488515_2630	SAMN04488515_1946	Putative signal transducing protein.	Hypothetical protein.	0.468

page 1 of 2

Network Stats

number of nodes:

5

number of edges:

7

average node degree:

2.8

avg. local clustering coefficient:

0.9

expected number of edges:

4

PPI enrichment p-value:

0.148

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0000209

Protein polyubiquitination

7 of 225

1.86

3.42

3.18e-09

GO:0016567

Protein ubiquitination

10 of 742

1.49

2.77

4.28e-11

GO:0070534

Protein K63-linked ubiquitination

3 of 33

2.32

1.95

0.00020

GO:0043161

Proteasome-mediated ubiquitin-dependent protein catabolic process

5 of 307

1.58

1.68

8.05e-05

GO:0019941

Modification-dependent protein catabolic process

6 of 608

1.36

1.46

6.65e-05

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0019787

Ubiquitin-like protein transferase activity

7 of 511

1.5

2.05

1.17e-06

GO:0004842

Ubiquitin-protein transferase activity

6 of 490

1.45

1.65

3.09e-05

GO:0061659

Ubiquitin-like protein ligase activity

4 of 362

1.41

0.86

0.0117

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:10284

Mixed, incl. Ubiquitin-like protein conjugating enzyme activity, and Protein sumoylation

6 of 103

2.13

3.69

1.34e-08

CL:10286

Mixed, incl. Ubiquitin conjugating enzyme activity, and Negative regulation of histone ubiquitination

5 of 60

2.28

3.6

5.82e-08

CL:10288

Mixed, incl. Ubiquitin conjugating enzyme activity, and Ubiquitin-dependent protein catabolic process via the N-end rule pathway

4 of 53

2.24

2.63

6.73e-06

CL:10289

Mixed, incl. Ubiquitin conjugating enzyme activity, and Ubiquitin-activating enzyme E1

3 of 42

2.22

1.67

0.00066

CL:10291

Ubiquitin conjugating enzyme activity, and Ubiquitin-activating enzyme E1

2 of 23

2.3

0.8

0.0346

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

dre04120

Ubiquitin mediated proteolysis

7 of 154

2.02

4.48

1.94e-11

dre04141

Protein processing in endoplasmic reticulum

3 of 197

1.55

1.02

0.0063

dre04137

Mitophagy - animal

2 of 87

1.72

0.74

0.0364

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

DRE-983168

Antigen processing: Ubiquitination & Proteasome degradation

7 of 303

1.73

2.92

1.92e-08

DRE-5696395

Formation of Incision Complex in GG-NER

3 of 42

2.22

1.81

0.00034

DRE-9708530

Regulation of BACH1 activity

2 of 10

2.66

1.45

0.0023

DRE-69052

Switching of origins to a post-replicative state

3 of 82

1.93

1.43

0.0014

DRE-975144

IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation

2 of 14

2.52

1.37

0.0030

(more ...)

WikiPathways

pathway

description

count in network

strength

signal

false discovery rate

WP324

Cytoplasmic ribosomal proteins

2 of 78

1.77

0.83

0.0243

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0035370

UBC13-UEV1A complex

2 of 2

3.36

1.55

0.0016

GOCC:1990234

Transferase complex

5 of 805

1.16

0.78

0.0088

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR013083

Zinc finger, RING/FYVE/PHD-type

5 of 371

1.49

1.21

0.0016

IPR019954

Ubiquitin conserved site

2 of 7

2.82

1.08

0.0113

IPR019956

Ubiquitin domain

2 of 9

2.71

1.04

0.0130

IPR011332

Zinc-binding ribosomal protein

2 of 9

2.71

1.04

0.0130

IPR001841

Zinc finger, RING-type

4 of 248

1.57

0.98

0.0082

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00212

Ubiquitin-conjugating enzyme E2, catalytic domain homologues

3 of 50

2.14

1.54

0.0011

SM00184

Ring finger

4 of 438

1.32

0.84

0.0108

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