node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Pnap_0317 | Pnap_0318 | Pnap_0317 | Pnap_0318 | KEGG: pol:Bpro_0463 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family-like. | PFAM: GtrA family protein; KEGG: pol:Bpro_0464 GtrA-like protein. | 0.765 |
Pnap_0317 | Pnap_0319 | Pnap_0317 | Pnap_0319 | KEGG: pol:Bpro_0463 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family-like. | PFAM: glycosyl transferase, family 9; KEGG: pol:Bpro_0465 glycosyl transferase, family 9. | 0.737 |
Pnap_0317 | queA | Pnap_0317 | Pnap_0321 | KEGG: pol:Bpro_0463 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family-like. | S-adenosylmethionine--tRNA-ribosyltransferase- isomerase; Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA). | 0.666 |
Pnap_0317 | recG | Pnap_0317 | Pnap_0322 | KEGG: pol:Bpro_0463 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family-like. | ATP-dependent DNA helicase RecG; Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y- DNA); Belongs to the helicase family. RecG subfamily. | 0.494 |
Pnap_0317 | tgt | Pnap_0317 | Pnap_0320 | KEGG: pol:Bpro_0463 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family-like. | tRNA-guanine transglycosylase; Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the [...] | 0.729 |
Pnap_0318 | Pnap_0317 | Pnap_0318 | Pnap_0317 | PFAM: GtrA family protein; KEGG: pol:Bpro_0464 GtrA-like protein. | KEGG: pol:Bpro_0463 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family-like. | 0.765 |
Pnap_0318 | Pnap_0319 | Pnap_0318 | Pnap_0319 | PFAM: GtrA family protein; KEGG: pol:Bpro_0464 GtrA-like protein. | PFAM: glycosyl transferase, family 9; KEGG: pol:Bpro_0465 glycosyl transferase, family 9. | 0.811 |
Pnap_0318 | queA | Pnap_0318 | Pnap_0321 | PFAM: GtrA family protein; KEGG: pol:Bpro_0464 GtrA-like protein. | S-adenosylmethionine--tRNA-ribosyltransferase- isomerase; Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA). | 0.709 |
Pnap_0318 | recG | Pnap_0318 | Pnap_0322 | PFAM: GtrA family protein; KEGG: pol:Bpro_0464 GtrA-like protein. | ATP-dependent DNA helicase RecG; Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y- DNA); Belongs to the helicase family. RecG subfamily. | 0.537 |
Pnap_0318 | tgt | Pnap_0318 | Pnap_0320 | PFAM: GtrA family protein; KEGG: pol:Bpro_0464 GtrA-like protein. | tRNA-guanine transglycosylase; Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the [...] | 0.822 |
Pnap_0319 | Pnap_0317 | Pnap_0319 | Pnap_0317 | PFAM: glycosyl transferase, family 9; KEGG: pol:Bpro_0465 glycosyl transferase, family 9. | KEGG: pol:Bpro_0463 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family-like. | 0.737 |
Pnap_0319 | Pnap_0318 | Pnap_0319 | Pnap_0318 | PFAM: glycosyl transferase, family 9; KEGG: pol:Bpro_0465 glycosyl transferase, family 9. | PFAM: GtrA family protein; KEGG: pol:Bpro_0464 GtrA-like protein. | 0.811 |
Pnap_0319 | queA | Pnap_0319 | Pnap_0321 | PFAM: glycosyl transferase, family 9; KEGG: pol:Bpro_0465 glycosyl transferase, family 9. | S-adenosylmethionine--tRNA-ribosyltransferase- isomerase; Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA). | 0.709 |
Pnap_0319 | recG | Pnap_0319 | Pnap_0322 | PFAM: glycosyl transferase, family 9; KEGG: pol:Bpro_0465 glycosyl transferase, family 9. | ATP-dependent DNA helicase RecG; Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y- DNA); Belongs to the helicase family. RecG subfamily. | 0.525 |
Pnap_0319 | tgt | Pnap_0319 | Pnap_0320 | PFAM: glycosyl transferase, family 9; KEGG: pol:Bpro_0465 glycosyl transferase, family 9. | tRNA-guanine transglycosylase; Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the [...] | 0.775 |
Pnap_1619 | tgt | Pnap_1619 | Pnap_0320 | PFAM: peptidylprolyl isomerase, FKBP-type; KEGG: pol:Bpro_3081 peptidylprolyl isomerase. | tRNA-guanine transglycosylase; Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the [...] | 0.578 |
Pnap_2686 | tgt | Pnap_2686 | Pnap_0320 | PFAM: peptidylprolyl isomerase, FKBP-type; KEGG: pol:Bpro_1864 peptidylprolyl isomerase, FKBP-type. | tRNA-guanine transglycosylase; Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the [...] | 0.578 |
guaA | queF | Pnap_2000 | Pnap_3164 | GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. | GTP cyclohydrolase I; Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1). | 0.569 |
guaA | tgt | Pnap_2000 | Pnap_0320 | GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. | tRNA-guanine transglycosylase; Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the [...] | 0.666 |
guaA | thyA | Pnap_2000 | Pnap_2772 | GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.402 |